... es with ana-kinra, a non-glycosylated form of the endogenous antago-nist of the IL-1 receptor, IL-1Ra, and rilonacept, whichbinds to IL-1b with high affinity and thus blocks the binding of ... eassociated with over-activation of caspase-1, the enzymewhich catalyses the c leavage of the precursor of IL-1b,pro-IL-1b, to generate a ctive IL-1b in excess [9]. ThissuggestedthatIL-1b blockade ... for the treatment of CAPS in children. Thereis, therefore, a need for improved anti-IL-1b therapies for the management of CAPS and other auto-inflammatoryconditions driven by overproduction of...