Báo cáo y học: "Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvemen" doc
Báo cáo y học: "Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvemen" doc
... tissue-type plasminogen activator; TNF:tumor necrosis factor; u-PA: urokinase-type plasminogen activator; u-PA-/-:urokinase-type plasminogen activator gene deficient; u-PAR: urokinase-type plasminogen ... 12:R37http:/ /arthritis- research.com/content/12/2/R37Page 12 of 13RESEA R C H ARTIC L E Open AccessUrokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex ... plasminogen activator and arthritis progression: role in systemic disease with immune complex involvement. Arthritis Research & Therapy 2010 12:R37.Submit your next manuscript to BioMed Centraland...
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Báo cáo y học: " Absence of xenotropic murine leukaemia virusrelated virus in UK patients with chronic fatigue syndrome" docx
... ecotropic Friend and Moloney MLV(Table 2) by assaying for a reduction in virus infectivityfollowing incubation of virus-containing supernatantFigure 1 Sensitivity of PCR screening for XMRV in PBMC ... UniversityQ125 + ++ ++ - ND+ indicates neutralising activity; ++ indicates strong neutralising activity; - indicates no neutralising activity; ND is no determined.Groom et al. Retrovirology 2010, ... neutralising activity that didnot inhibit VSV-G pseudotyped MLV in at least four human serum samples indicates that XMRV infection mayoccur in the general population, although with currently uncertain...
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Báo cáo Y học: Domain organization, folding and stability of bacteriophage T4 fibritin, a segmented coiled-coil protein docx
... enthalpy of the transition f or theE, SM4, SM1 and B1 fibritins increases linearly with anincreasing number of amino-acid r esidues in the coiled-coilregion. In contrast to the independent melting ... ofmelting between the C-terminal domain and the coiled-coilregion (Fig. 3A). Significant stabilization of fibritin M, in comparison with a wild-type fibritin, can be explainedmainly by two residues ... w ith a linear gradient o f NaCl. Fractionscontaining proteins were dialysed against Tris/EDTA bufferandstoredat4°C.The protein purity was judged by denaturing SDS/PAGEusing two systems: for...
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Báo cáo y học: "Fat-Storing Multilocular Cells Expressing CCR5 Increase in the Thymus with Advancing Age: Potential Role for CCR5 Ligands on the Differentiation and Migration of Preadipocytes" pot
... expression increased in the aging thymus. The CCR5 ligands, CCL4 and CCL5, increase in the thymic parenchyma as revealed by the age-associated increases in the staining of thymocytes and microenvironmental ... the thymus with age. Hy-pothesizing that the increased expression of chemokines and the CCR5 receptor may play a role in adipocyte recruitment and/ or differentiation within the aging thymus, ... proin-flammatory cytokines and fat-derived peptides termed adipokines (including ligands such as adi-ponectin, leptin, resistin, TNF-α, IL-6), which act in a paracrine, autocrine and/ or endocrine...
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Báo cáo y học: "Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis" potx
... immunos-timulatory mtDNA was involved in human arthritis by assay-ing the levels of extracellular mtDNA in plasma and synovialfluid (SF) samples from patients with rheumatoid arthritis (RA) and from ... bands were revealed bysilver staining. The gels were scanned and the intensity ofeach band on the gel was analyzed with IPLab Gel soft-ware (BioSystematica, Plymouth, UK). The value obtainedfor ... cel-lular injury [19], and high local levels have beenassociated with neuroinflammatory disease, for example in the brain tissues of patients with multiple sclerosis [20].Most interestingly, conditions...
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Báo cáo y học: "Review Ageing, autoimmunity and arthritis" pps
... alterations resem-bling those found in autoimmune diseases, especially in RA and in systemic lupus erythematosus (SLE) [19], exist in healthy aged individuals, including an increase in autoantibodies, ... of arthritis, but in ageing and in auto- immune diseases there is a complete disequilibriumbetween proinflammatory cytokines and anti-inflammatorycytokines [2,6,90]. In fact, this altered cytokine ... Activation and inhibition of lym-phocytes by costimulation. J Clin Invest 2002, 109:295-299.32. Dustin ML: Membrane domains and the immunologicalsynapse: keeping T cells resting and ready. J Clin Invest...
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Báo cáo y học: "Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development" docx
... clinical trials arepositive? The answer is this is ‘yes and no’. Certainly,skepticism and vigilance are required with industry-sponsored trials because there are inevitably large financialinterests, ... ofrheumatoid arthritis with methotrexate and hydroxychloro-quine, methotrexate and sulfasalazine, or a combination ofthe three medications: results of a two-year, randomized,double-blind, placebo-controlled ... generalize from our findings, and certainly if one looked at enough trials some exceptionswould be found. However, our results are confirmed bymany other studies. In a study of 61 industry-sponsoredtrials...
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Báo cáo y học: "Cardiovascular risk factors and acute-phase response in idiopathic ascending aortitis: a case control study" pptx
... artery specimens with activeinflammation [6]. Thus, the process of aneurysm formation in systemic inflammatory diseases is complex, multifactorial, and likely involves immune and proteolytic ... from hypertension, heritable disorderslike Marfan syndrome, bicuspid valve disease, and inflamma-tory and infectious processes. Among the systemic inflamma-tory diseases, thoracic aneurysms and ... plays a role in load bearing, and elastin, whichconveys elasticity to the aorta. Sex hormones play an impor-tant role in aortic wall compliance by regulating the elastin/col-lagen activity...
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Báo cáo y học: "Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis" docx
... primarily affects the synovial lining, resulting in destructivechanges to the joints and soft tissues, most commonly in thehand and wrist. Approximately 50% of patients with RA havetendon involvement, ... Galardy RE, Grobelny D, Foellmer HG, Fernandez LA: Inhibitionof angiogenesis by the matrix metalloprotease inhibitor N-[2R-2-(hydroxamidocarbonymethyl)-4-methylpentanoyl)]-L-tryptophan methylamide. ... [15].Hypoxia upregulated MMP-2 and MMP-9 activity in a variety ofadenocarcinoma cell lines and increased their invasiveness in vitro [16]. Crucially, there is evidence that MMPs are regulatedby...
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Báo cáo y học: "Toll-like receptors and NOD-like receptors in rheumatic diseases" pdf
... efficiently degrade cytosolic DNA [54].Ankylosing spondylitis, TLR2 and TLR4Ankylosing spondylitis is a multifactorial and polygenicinflammatory rheumatic disease with a poorly understoodpathophysiology. ... Joosten and colleagues have shown a proinflammatory role for NOD2 and an anti-inflammatory role for NOD1 in astreptococcal cell wall induced model of arthritis [30].Lyme arthritis and TLR2Lyme arthritis ... polymorphisms and susceptibility toankylosing spondylitis. There is good evidence for a linkbetween both Asp299Gly and Thr399Ile polymorphisms and ankylosing spondylitis [56], but no link with...
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