... article as: Wolfe and Michaud: The loss of health status in
rheumatoid arthritis and the effect of biologic therapy: a longitudinal
observational study. Arthritis Research & Therapy 2010 12:R35.
Wolfe ... 0.749)
Effect of biologic therapy on annual rates of progression of disability, loss of health status, and costs in patients pr...
... from a patient with a
1 year history of RA is shown in Figure 1.
Finally, animal studies are emerging to clarify the role of the
bone marrow as a site of pathology in RA. Marinova-
Mutafchieva and ... oedema at the bases of the 2nd and 3rd metacarpals and
adjacent regions of trapezoid and capitate carpal bones. Small intraosseous erosions are also apparent....
... will
hamper a clear adjudication of the reason for withdrawal.
In summary, the study by Saad and colleagues gives us
important insights into daily-life use of TNF inhibitors in PsA, a
disease that too often ... secondary to RA in the scientific and
clinical perceptions of rheumatologists. The authors deal
effectively with the challenges posed by the type and...
... (Biosource,
Camarillo, CA, USA), in accordance with the manufac-
turer's instructions.
Statistical analysis
Statistical analysis was performed using the Statview soft-
ware (Abacus Concept Inc., Cary, ... factor (TNF) bioactivity in rheuma-toid arthritis (RA) patients and healthy individualsPattern of plasma tumour necrosis factor (TNF) bioactivity in rheuma-
toid arthri...
... carbohydrate-specific anti-
bodies have not yet been systematically investigated in RA, in
spite of the fact that hyaline cartilage and synovial fluid contain
large amounts of GAGs including HA, ... bacterial peptidoglycans and the fungal
polysaccharide, Zymosan. Such cross-reactions may not only
explain the absence of anti-GAG antibodies in neonates, but
may also link i...
... underscored further by the findings that COMP mutations
cause human skeletal dysplasia, pseudoachondroplasia
(PSACH), and multiple epiphyseal dysplasia (MED) [18,19].
The clinical features of PSACH and ... phalangeal joints, metacarpal phalan-
geal joints, proximal interphalangeal joints, and distal inter-
phalangeal joints), and five points for a swollen ankle
(maximum score...
... injecting 99mTc-macroaggregated albumin
bubbles into the femoral artery as well as the antecubital
vein, an arteriovenous shunting ratio was calculated by
assessing the degree of pulmonary uptake after ... the high-output state being secondary to
innumerable intramedullary arteriovenous fistulas [1,2].
If this is the case, pharmacotherapy with the ability to tar-
get the under...
... simultaneous
activation of the inflammatory response and the clotting
cascade following tissue injury is a phylogenetically ancient
survival strategy. The linkage between coagulation and inflam-
mation ... Activation of
cells mediated by thrombin and other coagulation factors
increases proinflammatory cytokine synthesis and calcium
flux, alters intracellular signaling casc...
... physical health
summary score is mainly based on the physical health,
physical role limitations, bodily pain, and general health
components, whereas the mental health summary score is
mainly based ... envelope
when they underwent the examination at the out-patient
clinic. Each patient's respiratory symptoms and physical
health were assessed by a physician, nurse,...