Báo cáo y học: "Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel, liposomal delivery of dexamethasone phosphate: long-term suppression of arthritis facilitates interval treatment" pot

... articleSeparating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel, liposomal delivery of dexamethasone phosphate: long-term suppression of arthritis facilitates interval ... increased therapeutic potency of liposomal DXM-P resulted also in a significant reduction of urinary pyridinoline,indicating an inhibition of the ongoing, inflammation-mediatedbreakdown of collagen. ... period of 7 days. The onset of therapeutic improvement was substan-tially delayed when using daily injections of 0.4 mg/kg freeDXM-P (Figure 2a).We also determined concentrations of urinary pyridinoline...

Báo cáo y học: "Successful immunotherapy with matrix metalloproteinasederived peptides in adjuvant arthritis depends on the timing of peptide administration" pdf

... pathogenesis of rheuma-toid arthritis. J Rheumatol 1998, 53(suppl):S3-S7.2. Panayi GS, Lanchbury S, Kingsley GH: The importance of the Tcell in initiating and maintaining the chronic synovitis of rheumatoid ... administration wasrepeated four times with an interval of 3–4 days.Delayed-type hypersensitivity assayPeptides were dissolved in PBS (2 mg/ml) and 50 µl wasinjected in one ear. PBS was injected ... arthri-tis was scored by grading each paw from 0 to 4 based onerythema, swelling and deformity of the joints, resulting in a maximum score of 16.MHC class II–peptide binding assayLewis rat MHC class...

Báo cáo y học: " Work disability remains a major problem in rheumatoid arthritis in the 2000s: data from 32 countries in the QUEST-RA Study" doc

... formalexamination of sw ollen joints (swollen joint count using 28 joints, or SJC28) and tender joints (tender jointcount using 28 joi nts, or TJC28), global est imate of dis-ease activity, and erythrocyte ... severity. In an ideal world, a reduction of work disability rates in RA patients might be achievedby initiating early and aggressive treatm ent within someweeksormonthsofthefirstsymptoms[28].TheFin-nish ... Netherlands.5Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India.6Department of Internal MedicineII, Rheumatology, Schlosspark-Klinik Teaching Hospital of...

Báo cáo y học: "Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression" doc

... recent proof -of- principle study high-lighted the utility of these double-transgenic rats for arapid preclinical evaluation of the inhibitory potency and of the pharmacokinetic properties of antiviral ... geneexpression from the HIV-1 long terminal repeat (LTR)occurred in cell lines from mice and hamsters only in thepresence of Cyclin T1 of human origin [15]. Orthologues from mouse and hamster, in association ... remarkably, however, theintensity of GFP expression, reflected by the mean fluores-cence intensity (MFI) of individual infected cells ana-lyzed, drastically differed: infected human T-cellsdisplayed...

Báo cáo y học: " MRI bone oedema scores are higher in the arthritis mutilans form of psoriatic arthritis and correlate with high radiographic scores for joint damage" ppt

... obtained from review of a very large number of bonyregions (1013) by two readers working completely independ-ently in different institutions. A high degree of inter-reader reli-ability was demonstrated ... group than in those with non-AM ero-sive PsA, despite there being no evidence of greater diseaseactivity in terms of clinical scores (skin or joint) or inflammatorymarkers. Interestingly, the ... clinical assess-ments including collection of demographic data, as well as dis-ease activity scores (DAS) obtained from history, examinationand laboratory investigations including duration of...

Báo cáo y học: "Evidence for early disease-modifying drugs in rheumatoid arthritis" pps

... CombinationTherapy Trial Group: Delay to institution of therapy and induc-tion of remission using single-drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoid arthritis. Arthritis ... DG, SymmonsDP, Silman AJ: Influence of disease-modifying therapy on radi-ographic outcome in inflammatory polyarthritis at five years:results from a large observational inception study. Arthritis Rheum ... withcombination therapy at 2 years. Subsequent analysesfound that delaying DMARD therapy by only a few monthsdecreased the ability of the monotherapy to induce remis-sion [20]. The benefits of...

Báo cáo y học: "Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: complexities of interpreting nitric oxide measures" doc

... lines of evidence implicate NO in the pathogenesis of joint inflammation. Rodents in animal models of arthritis gener-Figure 3NOx/creatinine ratios in urine and serumNOx/creatinine ratios in urine ... shown in our study, individuals vary substantially in theirdietary intake of nitrate and nitrite. Unless individual variability of NOx intake is taken into account, measures of NOx in urineand ... correlationsmight be found by analyzing larger numbers of subjects.DiscussionNO is synthesized from L-arginine by a family of enzymesknown as nitric oxide synthases. These enzymes are encodedby three separate...

Báo cáo y học: "Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis" ppt

... Sugawara K, Ikenaka T: Conver-sion of peanut trypsin-chymotrypsin inhibitor B-III to a chymo-trypsin inhibitor by deimination of the P1 arginine residues in two reactive sites. J Biochem 1987, ... joint [14,37]. Neverthe-less, citrullinated fibrinogen is generated in inflamed synoviaarising from a variety of inflammatory conditions [37]. Ourobservation that ICs containing citrullinated ... autoantibody reactivity of processed citrullinated isoforms of vimentin in inflammatoryarthritides. Rheumatology (Oxford) 2008, 47:597-604.39. Matsuo K, Xiang Y, Nakamura H, Masuko K, Yudoh K, Noyori...

Báo cáo y học: "Trends towards an improved disease state in rheumatoid arthritis over time: influence of new therapies and changes in management approach: analysis of the EMECAR cohort" ppt

... efficienttreatment of RA in Spain. Throughout the follow-up of theEMECAR cohort, the percentage of patients without anyDMARD declined while the frequency of patients on combinedtherapy increased. In addition, ... funded by the Spanish Society of Rheumatology, the Spanish Foundation of Rheumatology, andby an independent research grant from Aventis, formerly from Hoechst Marion Roussel. IG-Á has in the ... filesAcknowledgementsThe EMECAR study was funded by the Spanish Society of Rheumatol-ogy, the Spanish Foundation of Rheumatology, and by an independent research grant from Aventis, formerly from Hoechst Marion...

Báo cáo y học: "MRI bone oedema scores are higher in the arthritis mutilans form of psoriatic arthritis and correlate with high radiographic scores for joint damage" ppsx

... addition of the PIP and DIP joints. Thesedata were obtained from review of a very large number of bonyregions (1013) by two readers working completely independ-ently in different institutions. ... clinical assess-ments including collection of demographic data, as well as dis-ease activity scores (DAS) obtained from history, examinationand laboratory investigations including duration of ... group than in those with non-AM ero-sive PsA, despite there being no evidence of greater diseaseactivity in terms of clinical scores (skin or joint) or inflammatorymarkers. Interestingly, the...

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