... proteins, including transcriptional regula-tors, chromatin-binding proteins and modifiers, protein-modifying factors, and chromatin assembly proteins. Importantly, knockdown of Oct4 protein levels ... other non-coding RNA, such as long intergenic non-coding RNA (lincRNA). Conversely, Oct4, Sox2 and Nanog, in concert with Polycomb group proteins (PcG), bind lineage-specic and non-coding RNA genes, ... and mental retardation due to dysregulation of gene expression [29]Nipbl Binds with mediator complex to allow loading of cohesion and formation of stable chromatin loop [29] Nipbl mutations...