... not Syk To identify regulatory factors involved in the activation of P38 kinase, we examined the effect of the tyrosine kinaseinhibitor, genistein, on the activation. Pretreatment of cellswith ... receptor tyrosinekinases, such as epidermal growth factor receptor.Decreased phosphatase activity, combined with high intrin-sic kinase activity of t he receptor tyrosine kinase, results in the ... yoshihom@fmu.ac.jpAbbreviations:UVB,ultravioletB;ROI,reactiveoxygenintermedi-ates; JNK, c-Jun N-terminal kinase; MAP kinase, mitogen activatedprotein kinase; ERK, extracellular signal-related kinase; P38, P38MAP kinase; PtdIns 3-kinase, p hosphatidylinositol...