... renal lesions, demy-elination, and edema of the brain.1 4, 46 48 1 , 4- Dioxane and cancer: Laboratory studies with animals exposed to 1 , 4- diox-ane showed induction of nasal cavity and liver carcinomas ... irritation of eyes, drowsiness, vertigo, headache, anorexia, stom-ach pains, nausea, vomiting, irritation of the upper respiratory passages, coma, and death. 1 , 4- Dioxane also caused hepatic and ... Toxicological prole for 1 ,4 dioxane (updated 2007). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. 47 . Material Safety Data Sheet. 2007. Safety data for 1 , 4- dioxane....