... the throat."Then they mixed all the "stuff" together and sprayed 1 cc of the mixture in each of the nostrils of 10 volunteers, and"into the throat, while inspiring, and on the eye" ... demonstrable seasonal variations,population variations, and a mechanism of action. To make sense of influenza's epidemiology, we reviseHope-Simpson theory, hypothesizing marked variation in the infectivity ... MS, Clarke M: Epidemiology of the HongKong-68 variant of influenza A2 in Britain. BMJ 1971,1:475-479.16. Hope-Simpson RE: The method of transmission of epidemic influenza: further evidence...