... ifference i n the internal ¯exibility of t he molecules. The rigid nature of the second b strand is consistent with the presence of the indole r ing of Trp25 bridging strands 1, 2 and 3. It should ... inhibitors.In the light of the solution structures reported here, weattempt to address the question of taxon-speci®c inhibitoryaction from the inhibitor side. The binding loops of each of the molecules ... in the P2¢ and P 3¢positions of the binding loop. The residues with the greatestDdNHvalues are Thr16 and, more interestingly, Gln35. The majority of the residues affected, including Thr16 and...