... regions of the proteininvolved in interaction with Cdk2 and cyclin A: 1, domain 1 interacting withcyclin A; 2, a linker helix involved in bindingboth cyclin A and Cdk2; 3, domain 2 inter-acting ... of p21Waf1 ⁄ Cip1 ⁄ Sdi1 to bind to and to inhibit a diverse family of cyclin–Cdk complexes,including cyclin A–Cdk2, cyclin E–Cdk2, and cy-clin D–Cdk4 [124]. Thus, the intrinsic disorder of p21Waf1 ... estrogen receptor a, and subunit A of calcineurin. Disordered regions appear to play important roles in the binding interactions of these hub proteins. The xeroderma pigmentosumgroup A protein (XPA)...