báo cáo khoa học:" Dimensional structure of the oral health-related quality of life in healthy Spanish workers" potx

... Health and Quality of Life Outcomes 2010, 8:24http://www.hqlo.com/content/8/1/24Page 5 of 9RESEARC H Open Access Dimensional structure of the oral health-related quality of life in healthy Spanish ... tobe the best approach to detect the underlying dimen-sions of the construct. The examiner ensured full com-pletion of the OHIP-14, before starting the interviewwith the OIDP. In both instruments, ... determine the adequacy of model fitting to the data. However, someshortcomings should be taken into account when inter-preting the findings, because although this method iden-tified the structure...

Tài liệu Báo cáo khoa học: Poly(ADP-ribose) The most elaborate metabolite of NAD+ Alexander Burkle pptx

... poly(ADP-ribosyl)ation of the dimerizationdomain of TRF2 as well as via noncovalent binding of poly(ADP-ribose) to the myb domain of TRF2 [102].This protein interaction may well be involved in modu-lating t-loop ... link between PARP-1 binding to non-BDNA structures in the genome and its function in the dynamics of local modulation of chromatin structure in normal cellular physiology (see below). Binding ... telomeresthrough binding of its ANK domain to TRF1. Thus the binding of TRF1 to telomeric DNA controls telo-mere length in cis by inhibiting the action of telo-merase at the ends of individual telomeres...

Tài liệu Báo cáo khoa học: A role for the intersubunit disulﬁdes of seminal RNase in the mechanism of its antitumor action docx

... thusblocking protein synthesis and leading cells to death. The current model proposed for the mechanism of antitumouraction of BS-RNase is based on the ability of the proteinto resist the neutralizing ... fetal bovine serum(Gibco -Life Technology) and Penicillin-Streptomycin-Glu-tamine 1X (Gibco -Life Technology). Cell lines were main-tained at 37 °C in a humidiﬁed incubator containing 10%CO2mixedwithair.Cytotoxicity ... plateau.These data indicate that the cell sulfhydryls responsiblefor the exchange with the protein disulﬁdes are located in the plasma membrane. Furthermore, they show that, asproposed in the hypothesis...

Báo cáo khoa học: A region within the C-terminal domain of Ure2p is shown to interact with the molecular chaperone Ssa1p by the use of cross-linkers and mass spectrometry doc

... from the X-ray structure of the C-terminal domain of Ure2p and integrates the finding that the N-terminal domain of Ure2p is flexible. An enlargement of the region of Ure2p involved in the interaction ... fibrilseither because of a change in the conformation of thisstretch or the crowding of a surface interface involved in intermolecular interactions within the fibrils or both.Alternatively, the inability ... solvent of the amino acid stretch spanning residues327–335 upon assembly of Ure2p into fibrils [33].Thus, the binding of Ssa1p in the vicinity of thisstretch interferes with Ure2p assembly into...

Báo cáo khoa học: Structural basis for the erythro-stereospeciﬁcity of the L-arginine oxygenase VioC in viomycin biosynthesis docx

... established by the hydroxyl group of the side chain of Ser224 and the carboxamide group of the side chain of Gln137. Gln137 is suitably ori-ented to interact with the a-amino group of l-arginine.These ... l-homoarginine and l-canavanine (Fig. 3A,Table 1). These ﬁndings can be explained by the coor-dination of l-arginine in the active site of VioC(Figs 4, 5 and 6B). As the stereochemistry of the Ca-atom ... concerning the adenylation domain(A-domain) speciﬁcity of VioF revealed b-ureidoalanineactivation, leading to the proposition of a new modelfor the order of the NRPSs during viomycin biosynthe-sis...

Báo cáo khóa học: Mechanistic insight into the peroxidase catalyzed nitration of tyrosine derivatives by nitrite and hydrogen peroxide doc

... to the afﬁnity of nitrite for the protein site where it is transformedinto the nitrating species, in the presence of the phenol.Interestingly, these constants resemble the reciprocal of the nitrite ... monitoring the absorbance changes at322 nm due to the formation of the oxidative couplingdimer of 4. The initial rates were determined from the linearpart of the trace at 322 nm. To convert the rates ... convenientlyfollowed through the increase of absorbance at 422 nm,due to the formation of the nitrophenolic derivatives, in the initial phase of the reactions. The conversion of the data from DAÆs)1toMÆs)1was...

Báo cáo khoa học: "Semantic Retrieval for the Accurate Identiﬁcation of Relational Concepts in Massive Textbases" ppt

... annotations3.2 On-line processing The off-line processing described above results in much simpler on-line processing. User input isconverted into queries of the extended region al-gebra, and the converted ... except for Query 2. In the following, wewill investigate the reasons for the residual errors.Table 9 shows the classiﬁcations of the errors of Disregarding of noun phrase structures 45Term ... Comparison of X-1 and X-2 clariﬁes the effect of using the term ontology. Comparison of X-2 and X-3 shows the effect of the event ex-pression ontology. The results for X-3 indicate the maximum...

Báo cáo khoa học: Sulfated polysaccharides inhibit the catabolism and loss of both large and small proteoglycans in explant cultures of tendon doc

... amounts of glycosaminoglycans remaining in the matrix.Measurement of turnover of 35S-labeledproteoglycans in tendon maintained in culture in medium containing varying concentrations of polysulfated ... 10 of the culture period, 62% of 35S-labeled proteoglycansremained in the matrix of cultures that had been main-tained in DMEM alone. However, in cultures main-tained in DMEM containing ... indicate that heparinwas more potent than CaPPS in inhibiting the loss of 35S-labeled proteoglycans from the matrix of tendonexplants. The rate of incorporation of [3H]serine into proteinsof...

Báo cáo khoa học: "Smart Paradigms and the Predictability and Complexity of Inﬂectional Morphology" docx

... have introduced the notion of smartparadigms, which implement the linguisticknowledge involved in inferring the in ection of words. We have used the paradigms to estimate the predictability of ... traditionally both treated as in- stances of the second declension, with the pluralending ar and the contraction of the unstressede in the case of nyckel. But in Hellberg, the word nyckel has nyck ... About3available in electronic form at http://www.eecs.qmul.ac.uk/˜mpurver/software.htmlone third of the nouns of the lexicon were not in- cluded in the experiment because one of the formwas missing. The...

Báo cáo khoa học: "A TOOL FOR THE AUTOMATIC CREATION, EXTENSION OF LEXICAL KNOWLEDGE" pdf

... aim of the user interface is to reduce user intervention in this checking phase to a minimum. It fully uses the functionality of the mouse, menu and window system of the Symbolics Lisp Machine. ... Dutch (i.e. in the definition of the primitive procedures which can be used by constructors), in the development of heuristics and diagnostic procedures, and in the design of the user interface. ... done interactively (each rule in the linguistic knowledge base can be easily turned on or off by the user). The result of applying this constructor to the MD is the extension of each entry in...

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