... chelatorssuggesting that the chelators may act intracellularly as well asat the cell membrane. In conclusion (a) rat hepatocytes have a much greater capacity to take up NTBI than the rat hep-atoma cell line ... anabnormally high absorption of Fe leading to saturation of the plasma Tf. Patients with the hereditary anemiathalassemia [4,5] also have increased plasma Fe, primarilydue to the obligatory treatment ... multidentate pyridinoneshave potential in the treatment of Fe overload, particularly atlower, more readily clinically available concentrations, andduring cancer chemotherapy, by removing plasma NTBI.Keywords:...