... inflammatorydiseases initiated an era of clinical investigation and estab-lished the foundation of modern clinical immunology. The original descriptions of antinuclear antibodies by Holman and Kunkel ... cells. In addition, signaling via CD20CommentaryB cells as a therapeutic target in autoimmune diseaseJörg J Goronzy and Cornelia M WeyandDepartments of Medicine and Immunology, Mayo Clinic, ... LaValley MP, Baldassare AR, Block JA, Caldwell JR,Cannon GW, Deal C, Evans S, Fleischmann R, Gendreau RM,Arthritis Research & Therapy Vol 5 No 3 Goronzy and Weyand133supporting the notion...