... Canada, 3Department of General Surgery, Nanshan Hospital, Shenzhen, Guangdong, China and 4Department of Pathology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, CanadaEmail: ... theclassic metastatic cascade again, which includes the pri-mary tumor cell local invasion, intravasation, circulation,adhesion and extravasation, survival and proliferation in the secondary organ [3,4,8,22,77]. ... liver and kidney of mice[31], and increased the adhesion of highly metastaticmurine carcinoma cell line H-59, and human colorectalcarcinoma lines HM 7 and CX-1 to murine hepaticendothelial cells...