báo cáo khoa học: " Highs and lows: patterns of use, positive and negative effects of benzylpiperazine-containing party pills (BZP-party pills) amongst young people in New Zealand" doc

... mortality of 20%.The single-centre trials utilize their investigators’ intimateknowledge of the strengths and weaknesses of the careprocesses and infrastructures of their institutions, and of therisk ... patients' risk profiles and familiarity with thecare processes and infrastructures of their institutions. An under-standing of the organisational and case-mix aspects of pre-, peri- and post-operative ... Physician, Professor of Intensive Care Medicine, Clinic of Intensive Care Medicine, University Hospital Bern (Inselspital), Bern, SwitzerlandCorresponding author: Jukka Takala, jukka.takala@insel.chPublished...

... checking the homo-...

... Doublesex- and Mab-3-related (DM)domain. Being a noncanonical cysteine-rich DNA-binding motif, this domain has two highly intertwinedfinger structures that chelate one zinc ion each, and binds to ... gathered in fish. Indeed,regarding Dmrt1, it is now obvious that because of consistent expression patterns in the gonads, and although necessarily acting at different stages of thesex-determining ... in developing germ cells (Table 2). In terms of inferred function(s), this incidentally indi-cates that paralogs of dmrt1 in fish, although obviouslynot involved in the first steps of gonadogenesis,...

... distance between and relative ori-entation of two fluorophores, being independent of thestrength of protein–protein interactions. In the case of very weak interactions as described in this article,rapid ... that induction of FRET does not sim-ply depend on the length of linkers. In the linker con-taining seven amino acids, a Pro-Pro sequence that isnot contained in other linkers is incorporated. ... citrine were introduced into CHO-K1 cells.As shown in Figs 1A and S1A, transiently expressedGAPDH–citrine (chimeric protein with N-terminalGAPDH and C-terminal citrine) and citrine–GAPDH(chimeric...

... proteins. Thus, the MEN1 ⁄ LEDGF-interactingdomain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHDdomains, the FYRN domain, the transactivatingdomain, ... protein-binding platformfor several other proteins to initiate a fundamental cel-lular process. P-TEFb binds to the N-terminal portion of AF4, whereas the C-terminal portion of AF4 con-fers binding ... be of great interest to analyze theWNT and TGFb signaling pathways in MLL-rear-ranged leukemias, asking whether the absence of activeWNT signaling (absence of WNT or FZD ⁄ LRP; pres-ence of...

... P, Atrian S & Capdevila M (1999)Replacement of terminal cysteine with histidine in themetallothionein a and b domains maintains its bindingcapacity. Eur J Biochem 259, 519–527.51 Harris ... Carlsbad,CA, USA) and positive clones were identified by PCRscreening. The identity of the insert was confirmed bysequencing both strands of the cloned inserts. In vitro protein expression and purificationPlasmids ... elegansmetallothionein isoform specificity – metal bindingabilities and the role of histidine in CeMT1 and CeMT2. FEBS J 276, 7040–7056.31 Blindauer CA, Harrison MD, Robinson AK,Parkinson JA, Bowness...

... RNA-cleaving and DNA-cleaving activitiesDazhi Jiang*, Jiacui Xu*, Yongjie Sheng, Yanhong Sun and Jin ZhangKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Jilin University, ... interference in the DNA-cleavingcatalytic domain of DRc DNAzyme. Reducing the RSto 6 bp increased the rate of DNA cleavage, whichapproached the self-cleaving rate of DRc DNAzyme in the absence of RS. ... constructedby incorporating the catalytic domain of 8–17 variantDNAzyme into the right domain of the secondarystructure of PL DNAzyme, demonstrating that dualactivities can coexist in a small...