... 86 a IU, international normalized ratio; ALT, alanine transferase; AST, aspartate transaminase; ALP, alkaline phosphatase; GGT, g-glutamyl transpeptidase; Br, bilirubin.Cheung et al. Journal ... structur ally related alkylatingagent, cyclophosphamide, are both activated in the liverby P450 oxidases, they are uncommon hepatic toxins[7], and it is suggested they can be used safely inpatients ... problems,nutritional deficits or parenteral feeding and polyphar-macy, which can affect susceptibility to acute liverinsult. Most hepatotoxic reactions associated with che-motherapy agents are idiosyncratic,...