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Báo cáo y học: "A randomized, double-blind, placebo-controlled trial to assess the efficacy of topiramate in the treatment of post-traumatic stress disorder" pot

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Báo cáo y học: " A randomized, controlled clinical trial: The effect of mindfulness-based cognitive therapy on generalized anxiety disorder among Chinese community patients: protocol for a randomized trial" pdf

... Our primary end point is the change of anxiety and worry score (Beck Anxiety Inventory and Penn State Worry Scale) from baseline to the end of intervention. For primary analyses, treatment ... participated in the drafting of the protocol for the intervention. WWSL participated in the coordination, as well as the revision of the manuscript. She also participated in the conduct of intervention. ... study will further inform the generalizability of our findings. Competing interests The authors declare they have no competing interests. Authors' contributions SYSW conceived of the...
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Báo cáo y học: "A Randomized Study of Epithelial Ovarian Cancer: Is Chemotherapy Useful after Complete Remission"

... not vary in relation to the number of cycles of chemotherapy given, (6 vs. 9 cycles of PAC [Platinum-Adriamycin-Cyclophosphamide] [19], 5 vs. 10 cycles of polychemotherapy with Cisplatin [20], ... our study with the exception of 1 case of grade 4 thrombocytopenia. Oddly, there were more relapses in lumboaortic-inguinal lymph nodes in the chemotherapy arm, however, in this study the different ... study examined 122 randomized patients in complete remission as judged by laparoscopy or laparotomy following first-line chemotherapy consisting of ACy (Adriamycin + Cyclophosphamide), PCy (Cisplatin...
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Báo cáo y học: "β A randomized, controlled trial of interferon-β-1a (Avonex®) in patients with rheumatoid arthritis: a pilot study [ISRCTN03626626]" pptx

... fever. Efficacy The primary efficacy end point of the study was the ACR20 response at the completion of the 24-week study(Table 3). In the intention -to- treat (ITT) responder-at-end-point analysis, ... irrespective of study completion status.Discussion The goal of this study was to assess the effects of IFN-β-1a in the treatment of RA. The decision to consider the use of this therapy in RA was ... twogroups.Keywords: clinical trials, cytokines, interferon-β, rheumatoid arthritis, therapyOpen AccessR73basis of the known side effects of the study agent), includ-ing flu-like symptoms occurring...
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Báo cáo y học: "A randomized controlled trial evaluating the impact of knowledge translation and exchange strategies" docx

... maker working in an organization sup-portive of evidence-informed decision making, leads to outcomes in the hypothesized direction. In addition, sim-ply having access to an online registry of research ... findings that policy-makers were more likely to use the results of technology assessments when theyrequested information, and when they received the infor-mation while still engaged in making ... strategies individually or in comparison to oneanother, the timing was right for conducting this study.Healthy body weight The problems of obesity, overweight, and physical inactiv-ity have been...
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Báo cáo y học: " A randomized controlled pilot study of a brief web-based mindfulness training" docx

... were used to calculate the number of days they participated. At the end of the training participants were asked 13 questions, how they liked the training, whether they were able to use the techniques ... those reported in the manuals of the instruments (Table 2). General distress. The global score (GSI) of the German Brief Symptom Inventory (BSI) [26], the 53 item version of the Symptom Checklist-90-R, ... with information regarding their group-assignment within a day after they had completed the screening. We chose this approach to minimize information delay regarding the beginning date of the...
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Báo cáo y học:

Báo cáo y học: "A randomized, double-blind, placebo-controlled trial to assess the efficacy of topiramate in the treatment of post-traumatic stress disorder" pot

... compare the efficacy of topiramate with pla-cebo in the treatment of PTSD, and will study its tolerabil-ity through the drop out rate in each group. The primaryhypothesis is that topiramate ... superior to placebo in the treatment of PTSD. Secondary research goalsincludes studying the efficacy of topiramate in socialadjustment, functioning and quality of life. Additionally,evaluating treatment ... CentralPage 1 of 7(page number not for citation purposes)BMC PsychiatryOpen AccessStudy protocolA randomized, double-blind, placebo-controlled trial to assess the efficacy of topiramate in the treatment...
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Báo cáo y học: "A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL 1R1) in patients with osteoarthritis of the knee" pdf

... study. Endpoints The primary endpoint in Part A of the study was the safety of AMG 108; additional endpoints included the PK of AMG 108. In Part B, the primary endpoint was the clinical efficacy ... efficacy of AMG 108 (change from baseline to week 6 in the WOMAC pain score); additional endpoints included the safety and PK of AMG 108. Safety endpoints in both parts of the study included treatment- emergent ... disease, or hypertension); or any other condition that, in the opinion of the investigator, would interfere with the interpretation of the study results. time points (n=4 per time point): day 2,...
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Báo cáo hóa học: "A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899" pot

... demonstratedactivity with estramustine-based combinations and the activity of combined navelbine and mitoxantrone, sup-porting the testing of combination therapy with estra-mustine, mitoxantrone, and vinorelbine ... at the beginning of eachcycle. Conditions for dose modification in the case of toxicity were specified in the protocol. Efficacy and SafetyResponse and progression were assessed according to RECIST ... health-relatedquality of life in the clinical evaluation of novel cytostatic agents?:Commentary re: P. M. LoRusso, Improvements in quality of life anddisease-related symptoms in phase I trials of the selective...
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Báo cáo y học: "A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy" pps

... Increased Following the 12 week trial, 15 of 17 patients opted to continue Apatone therapy. Any decision to remain on Apatone therapy was left entirely to the patient. Anecdotally, most patients ... organs.9 The purpose of this study was to evaluate the safety and efficacy of oral Apatone administered throughout the day in prostate cancer in patients who failed standard therapy. Int. J. ... co-administration of Apatone with known chemotherapeutic agents in other cancers resulted in a synergistic increase in antitumor activity.8,20 These results suggest that Apatone may find use in the clinic...
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Báo cáo y học: "Health system weaknesses constrain access to PMTCT and maternal HIV services in South Africa: a qualitative enquiry" pptx

... documented a series of delays, coupledwith a lack of access to information and support at keypoints in the care continuum. Several broad themesemerged in a nalysis. These are g rouped in the sequenc ... registering upwards of 50%[20]. Nurses interviewed spoke of the challenge of attracting and retaining health personnel in the EasternCape, especially in certain peri-rural towns. At the East-ern ... explicitlyemphasized confidentiality. Further, the analyses, inter-pretation and conclusions may not be generalisable to other parts of the country, even though many findingswere common across the...
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