... significantly associated with change in medial femoral and lateral tibial cartilagedefects over 2 years after adjustment for age, sex, BMI, familyhistory of OA and past knee injury. Furthermore, ... became nonsignificant afteradjustment for tibial bone area and osteophytes. This studysuggests that increasing body mass index and bone size, pastknee injury, and osteophytes may be causally ... individ-ual cartilage plates (medial tibia and femora, and lateral tibiaand femora) were isolated from the total volume by manuallydrawing dis-articulation contours around the cartilage bound-aries...