... pathways results in developmental disor-ders, cancer, fibrosis and autoimmune disorders. Signa-ling is initiated by binding of the cytokine to ahomodimeric complex of cytokine receptor type II,which ... 1381through binding to GCL [11]. Lamin A binds the transcription repressors retinoblastoma protein (pRb)and MOK2 (reviewed in [1,12]). Finally, the nuclearenvelope protein MAN1, the subject ... Prelamin A and BAF are also bindingpartners of emerin [39]. Interestingly, the N-terminusof human MAN1 binds the human emerin itself(Fig. 1; [8]). Emerin is an integral membrane proteinand...