... similarity to the prodo-main of cruzipain, the similarity of the mature domainof cathepsin F to that of cruzipain is higher (48%)than that between the mature domains of cruzipainand cathepsin ... the main cathepsin L-like CP from the worm Fasciola hepatica was described as highly select-ive for the parasite’s enzymes, being practically inca-pable of inactivating mammalian cathepsins ... cathepsin F To evaluate the selectivity of PCZ as an inhibitor ofpapain-like enzymes, the propeptide was incubated for30 min with papain or human cathepsins B, L, S, K, Vand F (in the subnanomolar...