... cell shrinkage (pyknosis) and nuclear fragmentation (karyorrhexis) [52]. The regula-tion of apoptosis in sepsis is complex, as the infectingpathogen may inhibit or induce apoptosis, involvingboth ... anti-inflammatory cyto-kines. The coagulation pathway is also activated by LPS-mediated signaling and further regulated by the cyto-kines, inducing the production of tissue factor, pro-thrombin conversion ... the magnitude and duration of global tissue hypoxia, is useddiagnostically, therapeutically and prognostically. This study examined the association of early lactate clearance with selected inflammatory,...