... substrates it will bind and catalyze. In particular, in the series benzylamine, dopamine, and tryptamine, primary kinetic isotope effects range from a low of 4.8 in benzylamine to a high of 54.7 in ... mutually exclusive, and are probablyall involved in catalysis to a greater or lesser extent in eachenzyme system.One of the earliest and still widely accepted ideas used to explain this catalytic ... 2002 Barrier passage and protein dynamics (Eur. J. Biochem. 269) 3111MINIREVIEWBarrier passage and protein dynamics in enzymatically catalyzedreactionsDimitri Antoniou1, Stavros Caratzoulas1,*,...