báo cáo khoa học: " ’It’s risky to walk in the city with syringes’: understanding access to HIV/AIDS services for injecting drug users in the former Soviet Union countries of Ukraine and Kyrgyzstan" ppt

... explanatory insightsinto the problems of accessing HIV/AIDS services. The aim was to develop a better understanding of the nat-ure and complexity of factors that obstruct access rather than to ... said they valued this ‘peer -to- peer’ princi-ple. For example, a former client and volunteer in Ukraine explained: ‘ as a former injecting drug user and being HIV positive, with a wife and children, ... of Drug Policy 2007, , 18:136-140.doi:10.1186/1744-8603-7-22Cite this article as: Spicer et al.: ’It’s risky to walk in the city with syringes’: understanding access to HIV/AIDS services for...

Tài liệu Báo cáo khoa học: AcmA of Lactococcus lactis is an N-acetylglucosaminidase with an optimal number of LysM domains for proper functioning ppt

... differences. In conclusion, the number of LysM domains present in the protein determines the binding efﬁciency of the protein, with optimal binding when three LysM domains arepresent. The results of the ... amidases, hydrolyzing the bond between the glycan chain and the peptide side chain, and peptidases of varying speci city. AcmA is the major autolysin of the Gram-positivebacterium Lactococcus lactis ... by keeping the protein attached to the cell wall substrate.A fusion protein consisting of the antigen MSA2 and the C-terminus of AcmA binds to speciﬁc loca-tions on the cell surface of Gram-positive...

Báo cáo khoa học: Human mesotrypsin exhibits restricted S1¢ subsite speciﬁcity with a strong preference for small polar side chains docx

... responsible for the resistance of mesotrypsin against canonicaltrypsin inhibitors [3–5]. To determine the role of Arg198 in the resistance of mesotrypsin against a1AT,Arg198 was substituted with Gly, the ... obstruc-tion of the S1¢ site. The original objective of this study was to test whe-ther the serpin inhibitory mechanism can overcome the inhibitor resistance of human mesotrypsin. The rational for this ... trypsin activitywas plotted against inhibitor concentration and the equival-ence point was determined from the y-intercept of the extrapolation of the linear portion of the titration curve.The...

Báo cáo khoa học: It’s cheap to be colorful Anthozoans show a slow turnover of GFP-like proteins potx

... photo-conversion involves cleavage of the polypeptide chaininto two fragments of  20 and  8 kDa [6,29,40,42].Therefore, the amount of both fragments is indicative of the amount of the red form. ... radiation in vivo and in situ. In the absence of photoconverting light, we subsequentlytracked degradation of the red-converted forms of the two proteins in coraltissue using in vivo spectroscopy and ... DiscussionPhotoconversion in vivo and in situ To measure protein degradation in red-converted forms of mcavRFP and EosFP by monitoring the decay in redﬂuorescence in the tissues of red morphs of M. caver-nosa and...

báo cáo khoa học: " It''''s time for Canadian community early warning systems for illicit drug overdoses" pdf

... characteristics of the substance and the potential risks, the better able they are to make informedchoices about their drug use. Involving people with addic-tion in the reporting and disseminating of overdose ... source, and avoid mixing drugs with simi-lar effects. Evaluation of a cohort of injection drug users in Vancouver found the following factors increased risk of non-fatal overdose: cocaine and heroin ... circulating in their communi-ties and by targeting them in the dissemination of warnings and alerts once a threat has been detected.Involvement of people with addiction in the planning and implementation...

Tài liệu Báo cáo khoa học: Afﬁnity and kinetics of proprotein convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells docx

... reac-tion in which the ﬁrst binding step, representing bind-ing to the EGF-A domain, is followed by binding of PCSK9 to a second site within the receptor. In thismodel, dimeric and monomeric receptor ... PCSK9 binding to HepG2 cells. First, the number of LDLRs on HepG2cells increased following growth in the absence of lipo-proteins, and there was a corresponding increase in the binding of [125I]TC-PCSK9 ... observation is in marked contrast to what isseen in many receptor systems, including the insulinreceptor [26], where lowering of the pH leads to disso-ciation of ligand from receptor. The reduced...

Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of ﬂavoproteins: photosynthetic electron transfer from photosystem I to NADP+ doc

... approach and colinear orientation of the N5 of the flavin, the hydride to be transferred, and C4 of the nicotinamide. In FNR, displacement of the C-terminal Tyr appears to be required for the interaction ... protein–flavin complexes and tailor the midpoint potentials in these proteins, aswell as many details of the binding and electron transfer to protein and ligand partners, have been revealed. In ... C-terminal Y303 in AnFNR. The two one-electron midpoint potentials of the fla-vin in FNRs are close to each other, therefore theseproteins stabilize only 10–20% of the maximal amount of semiquinone...

Tài liệu Báo cáo khoa học: It is all about resolution Meeting report based upon presentations at the 10th International Global BioMillennium 2006 symposium on molecular cell biology (Tbilisi, Georgia) docx

... developmentalregulation of gene expression. Certain SR and hnRNPproteins shuttle continuously between the nucleus and the cytoplasm. Interestingly, hnRNP A1 binds to and isnecessary for the processing of a cluster ... Ger-many). In the absence of interferon, STAT2 perma-nently and rapidly shuttles between the cytoplasm and the nucleus. A region in the C-terminus of STAT2controls its speciﬁc export in the absence of ... probe with a sequencecomplementary to telomeric DNA. Engineering of fusion proteins of telomere-binding proteins with yel-low ﬂuorescent protein and time-lapse imaging wereused to follow the...

Tài liệu Báo cáo khoa học: Aldehydes release zinc from proteins. A pathway from oxidative stress⁄lipid peroxidation to cellular functions of zinc pptx

... signaling and gene expression.ResultsAldehydes release zinc from zinc-binding proteins The effect of aldehydes on the zinc-binding capacity of zinc proteins was assayed by employing spectropho-tometry ... functions of zinc and MT againstethanol toxicityBoth zinc and MT protect the liver and the heartagainst the toxic effects of ethanol [45–47]. The aboveresults suggest that a critical aspect of the ... recorded. With the exception of formaldehyde, none of the aldehydes affects the absorbance of PAR. The data for the reaction of MT with formalde-hyde were corrected for the absorbance changes in the absence...

Tài liệu Báo cáo khoa học: Interactions between M proteins of Streptococcus pyogenes and glycosaminoglycans promote bacterial adhesion to host cells pdf

... mediate binding to proteins involved in hostdefence. Known relevant ligands for GAGs include growthfactors, cytokines and other mediators of in ammation [3].Hence, trapping of these mediators ... to the A–B3 region, IgGFc-binding to the S-domain, and albumin-binding to the C-repeats [31].Recombinantly expressed fragments rA–S and rS–C3 are indicated. (D) The M1 protein and the A–S and ... in the NH2-terminal part of M1 and M5 and in the C-repeatedregion both are required for the interaction with GAGs. The observation that the C-repeats are important for the binding of GAG to...

Xem thêm