báo cáo khoa học: " Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer’s disease" doc

... http://genomemedicine.com/content/2/11/83doi:10.1186/gm204Cite this article as: Orešič M, et al.: Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer’s ... avenues.Bioinformatics tools enabling a systems medicine approach to ADMany tools are available for mining of heterogeneous biological data, although the focus of such tools and the challenges ... conceived and wrote the manuscript. JL and HS critically reviewed the manuscript and contributed to its writing.Author informationMO is a Research Professor of systems biology and bioinformatics....

báo cáo khoa học: " Systems medicine and integrated care to combat chronic noncommunicable diseases" docx

... University of Ireland, Maynooth, Co. Kildare, Ireland. 52Department of Systems Biology and Bioinformatics, University of Rostock, 18051 Rostock, Germany. 53Faculty of Medicine, University of Maastricht, ... clinical and patient-reported disease markers. It uses the power of computational and mathematical modeling to enable understanding of the mechanisms, prognosis, diagnosis and treatment of disease ... taking into account points of view, habits of mind, and all the information requested for the needs of the strategy. e educational program needs to forge educational systems to help participants...

Báo cáo khoa học: Afﬁnity puriﬁcation-mass spectrometry Powerful tools for the characterization of protein complexes ppt

... nuclearpre-mRNA and to catalyze the accurate removal of introns and ligation of exons to yield a mature mRNA. The afﬁnity of the splicing complexes to RNA was used in this approach for the isolation of the ... from the sequence.However, this stretch of consecutive sequence is ÔlockedÕwithin the peptide by the masses of the fragments that deﬁne the beginning and the end of the determined sequence.Information ... successfully in the past and antibodies against these tags are commercially available. The underlying advantage of the approach is the highdegree of reproducibility of the results because standardizedtechnical...

Báo cáo khoa học: Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis pdf

... dissociation of these twoproteins inhibits the antiapoptotic activity of Bcl-2 byinitiating the release of cytochrome c from mitochon-dria into the cytosol and increasing the activities of caspase 3 and ... mediates the interactionwith Bcl-2 and other close Bcl-2 homologs, such asBcl-xL and Mcl-1 [45]. Mutation of the BH3 domain of Beclin 1 or of the BH3 receptor domain of Bcl-2 ⁄Bcl-xL abolishes their ... pocket formed by the BH1–3 domains [61].Following an apoptotic stimulus, Bax changes confor-mation, leading to the exposure of the C-terminal tail and the translocation of active Bax to the mitochondrialmembrane...

Báo cáo khoa học: Oxidative stress and apoptotic events during thermal stress in the symbiotic sea anemone, Anemonia viridis potx

... respectiveimplication of both partners in the phenomenon. In the zooxanthella, heat stress has been demonstrated toreduce the photosynthetic rate by decreasing the efﬁ-ciency of the photosystem II [4–6] and ... degeneration[8,9,53,56] and ⁄ or gastrodermal detachment [7,52,57].Nevertheless, independently of the resulting effect of the thermal stress, all mechanisms point to the involve-ment of oxidative stress in the ... (p20) subunit in bold and the small subunit ﬁt between the two domains.Residues boxed are the component of substrate binding site. Asterisks indicate the His and Cys residues of the putative active...

Báo cáo khoa học: "Clinical efficacy and problems with CT lymphography in identifying the sentinel node in breast cancer" docx

... identify the lymph vessels and lymph nodes. The breakdown of the identification by CTLG showed clearenhancing of the lymph nodes in 88% of the patients,while in 5% of the patients identification of ... identification rates by CTLG and the dye-guided methodIdentification of the SN(s) was achieved in 212 (96%) of the total 221 performances of CTLG. The number of World Journal of Surgical Oncology 2008, ... treated at the TokushimaBreast Care Clinic. SN identification was performed bycombined application of CTLG and a dye-guided method.In two of the patients the CTLG was performed before and after...

Tài liệu Báo cáo khoa học: What makes biochemical networks tick? A graphical tool for the identiﬁcation of oscillophores ppt

... each other). The value (the sign) of a cycle is the product of the values (the signs) of its steps. The sign o f the magnitude of a Ôminus combined autoinfluence path of order pÕ equal those of the ... containparallel and antiparallel arrows). The sign of that elementtherefore depends on the both the sign and the magnitudes of these influen ce paths (see below). If all its i nfluence pathsare positive, the ... subgraphs of the same order in the same network, as was illustrated for the two examples inthis paper. The network outside the former s ubgraphmay do away with the oscillophoretic potential of the subgraph...

Báo cáo khoa học: "Word Clustering and Word Selection based Feature Reduction for MaxEnt based Hindi NER" ppt

... measures the similarity of the contexts of the occurrences of the word in terms of the prox-imal words.3.3 Similarity based on Proximity to NECategoriesHere, for each word (wi) in the corpus ... using the important words for previous two and next two positions along with the suffix, prefix,digit and POS information.5.3 Relative Effectiveness of Clustering and Word SelectionIn most of the ... matches, then set 1 to the corresponding position of the vector and set zeroto all other positions related to List P rev. Sim-ilarly check the next word (wk+1or wk+2) in the List Next and find the...

Báo cáo khoa học: "Paragraph-, word-, and coherence-based approaches to sentence ranking: A comparison of algorithm and human performance" ppt

... i, k is the kth word in sentence i, tfjk is the frequency of word k in document j, nd is the number of documents in the reference corpus, and dfk is the number of documents in the reference ... and Experiment 2 for any of the 15 texts (all Fs < 1). Therefore, in order to lend more power to our statistical tests, we collapsed the data for each text for the WithParagraph and the ... Nucleus, and a less important discourse segment, or a Satellite (Marcu (2000)). The Nucleus is the equivalent of the arc destination, and the Satellite is the equivalent of the arc origin in the...

Báo cáo khoa học: Photodynamic treatment and H2O2-induced oxidative stress result in different patterns of cellular protein oxidation ppt

... described above for 1D gels. After blotting of the two-dimensional gels (before blocking of the membrane and application of the antibody), the membranes werestained with Ponceau Red and scanned.4860 ... (PDT). The mode of cell death by PDT may beeither apoptosis or necrosis, depending on the nature and concentration of the photosensitizer and the amount of irradiation [3,4].Although the signaling ... the site of their generation[2]. In this way, the intracellular localization of the photosensitizer determines the areas of its photodynamicaction. Molecular targets of oxidation may therefore...

Xem thêm