... Differential activation of the inflammasome by caspase 1 adaptors ASC and Ipaf. Nature 2004, 430:213-218.17. Yamamoto M, Yaginuma K, Tsutsui H, Sagara J, Guan X, Seki E, Yasuda K, Yamamoto M, Akira ... Duncan JA, Bergstralh DT, Wang Y, Willingham SB, Ye Z, Zimmermann AG, Ting JP: Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling. Proc Natl ... sug-gesting that the presence of distinct combinations of ASCsplice variants might potentially affect inflammasomeactivity at different stages of the inflammatory response.ASC-b lacks amino acids...