... atherosclerotic lesion. Inparticular, the elaboration of interleukin -1 (IL -1 ) (34–36), interleukin-6 (IL-6)(37–39), and tumor necrosis factor alpha (TNF-α) (40, 41) augment the expres-sion of adhesion ... highest quartileof hs-CRP had a 2-fold increased risk of future stroke (RR 1. 9; 95% CI 1. 1–3.3), a 3-fold higher risk of future MI (RR 2.9; 95% CI 1. 8–4.6) (12 4), and a4-fold higher risk of ... middle-aged healthy Europeanmen, a 1 SD increase in log-normalized baseline hs-CRP was associated with a 1. 7-fold higher risk of a first major coronary event (95% CI 1. 29–2 .17 ) (12 6). Ina nested-case...