báo cáo khoa học: " Seed-specific elevation of non-symbiotic hemoglobin AtHb1: beneficial effects and underlying molecular networks in Arabidopsis thaliana" doc

... signal-ing. Calcium signaling is linked to NO signaling pathways[52,53] and possibly directly involved in the regulation of hemoglobin expression [54]. NO induces a rapid increase in calcium ... signaling seemsto play a role in the hypoxic response of WT, as indi-cated by the upregulation of six transcripts encodingcalmodulins and calmodulin binding proteins, accompa-nied by an induction ... metabo-lism/signaling is consisten t with an overrepresentation of ABRE binding sites in the 5’-flanking regions of AtHb1 coexpressed genes (Table 3). Auxin transport and signaling is commonly downregula ted in...

báo cáo khoa học: " The impact of bisphosphonates on the osteoblast proliferation and Collagen gene expression in vitro" ppsx

... Non-nitrogen-containingbisphosphonates are build into ATP resulting in a non-hydrolysable adenine containing metabolite, whereasnitrogen-containing bisphosphonates interfere with themevalonate pathway by inhibition ... classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number ... Rogers MJ: Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res 1998, 13:581-589.10....

báo cáo khoa học: " Release kinetics of VEGF165 from a collagen matrix and structural matrix changes in a circulation model" pot

... surgery.BackgroundTheuseofvirtualplanningtorestoretissuethatwaslostduetotraumaortumorsurgeryisbecomingmorepopular in reconstructive surgery. Particularly in com-plex anatomical situations in volving different sorts of tissue, the use of CAD/CAM applications facilitatesplanning and execution. ... vir-tually using computer software. Models and t emplatesbuilt through rapid prototyping allow the surgeon tobring the planning to the operating theatre and closethe gap between set-up and execution. ... widespread in craniomaxillofacial surgery, but also other specialties areusing this techniques in their clinical routine [1,2]. Therapid prototyping approach allows the creation of anydesired...

báo cáo khoa học: " Release kinetics of VEGF165 from a collagen matrix and structural matrix changes in a circulation model" pptx

... remodelling is an integral part also of the mecha-nism of bone healing and regeneration of bony defaults. In the process of bone healing and regeneration, bio-chemical procedures follow a well-defined ... natural healing and regenerating processes.Our in- vitro trial substantiates the position of cytokinecollagen complexes as innovative and effective treatmenttools in regenerative medicine and paves ... differentiation of chondrocytes and osteoblasts. An increase in VEGF is an indication of increased vascular permeability and microvascular activ-ity, including angiogenic growth of new blood vessels [7-9].VEGF...

Tài liệu Báo cáo khoa học: Identiﬁcation of two late acyltransferase genes responsible for lipid A biosynthesis in Moraxella catarrhalis doc

... two mutants in bacterial clearance might reflectdifferences in the integrity of their outer membrane,binding activity and sensitivity of the murine comple-ment-mediated killing. In conclusion, ... identificationusing primers b1X and b1B, and the inactivated lpxXmutant was verified by sequencing.Cloning of lpxL and construction of the knockoutmutant O35ElpxLA DNA sequence containing the lpxL ... lane 2; Fig. 2D,lane 4), and none was detected in that of O35E(Fig. 2B,D, lane 1), showing a single insertion into thegenome of each mutant.To determine whether the insertion had a polareffect...

Tài liệu Báo cáo khoa học: Biochemical characterization of human 3-methylglutaconyl-CoA hydratase and its role in leucine metabolism docx

... usingcrotonyl-CoA as a substrate [15]. The gene encodingthis bifunctional protein was named AUH (‘AU bind-ing homolog of enoyl-CoA hydratase’). The RNA-binding activity of the human protein ... protein (AUHp40). Westernblot analysis of brain extracts consistently revealed a32 kDa AUH protein and it was thus assumed thatthe mature form of human AUH in brain has a molecular weight of ... inclu-ding equilibration, was 10 min. A splitter between theHPLC column and the mass spectrometer was used, and 100 lLÆmin)1 of eluent was introduced into the mass spec-trometer. A LCT TOF...

Tài liệu Báo cáo khoa học: "Semantic Classification of Noun Phrases Using Web Counts and Learning Algorithms" ppt

... relation. 2.2 Machine Learning Algorithms We are also interested in comparing the perform-ance of machine learning algorithms on the task of mapping from n-gram frequencies of joining terms to ... conditions, and again using all of the joining terms produced the best results. The SVM algorithm produced the best accuracy of all, achieving 50.1% accuracy using the com-bined set of joining ... containing the modifier, noun, and a prepo-sitional joining term. We compare and evaluate different algorithms and different joining phrases on Nastase and Szpako-wicz’s (2003) dataset of 600...

Tài liệu Báo cáo khoa học: Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner pptx

... leading to in uterodeath at E15 [2,3]. The c-Myb protein consists of anN-terminal DNA-binding domain (DBD), a central trans-activation domain (TAD) and a C-terminal negativeregulatory domain ... several subdomains of c-Myb revealed strongestsubdomain interaction with the EVES-domain in the NRD-region of c-Myb, suggesting that this region might beinvolved in the UBC9 interaction (results ... cause secondary effects resulting in the observed increased activity of 2KR. Theemerging picture of the functional nuclear architectureconsisting of specialized domains with distinct biologicalfunctions...

Báo cáo khoa học: Functional dissection of Escherichia coli phosphotransacetylase structural domains and analysis of key compounds involved in activity regulation potx

... containingthe last 326 amino acids in the case of Pta-F1, the last 352amino acids in the case of Pta-F2, and the last 470 aminoacids in the case of Pta-F3 (Fig. 2).PCR reactions performed in ... islocated in the C-terminal domain, the E. coli PtaN-terminal domain is involved in stabilization of thehexameric native structure, in expression of the max-imum catalytic activity, and in allosteric ... domain. Taking into account the importantrole of Ptas, the results obtained in the present work,dissecting the different domains forming E. coli Pta,will help in the future manipulation of...

Báo cáo khoa học: The effect of replacing the axial methionine ligand with a lysine residue in cytochrome c-550 from Paracoccus versutus assessed by X-ray crystallography and unfolding ppt

... prominent beingthe absence of the 695-nm band, indicative of Met-Sd-iron coordination. Upon titrating increasing amounts of guanidinium hydrochloride (GdmHCl) the proteinunfolds resulting in the ... reﬂection of the more basic f-amino group of the coordinating K100, with the H-bonded watermolecule found in the X-ray structure increasing theelectron donating power of the coordinating aminogroup ... perturbation of a number of electronic absorption bands and the appearance in thespectrum of new ones. One of these, a band at623 nm, grows into the spectrum indicating a changefrom low- to high-spin...

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