... shedding and spread, which could inform the decision regarding whether to institute antiviral therapy and help in determining the pathogenicity of the virus, wemeasured the PLI in four consecutive critically ... helpful together with the PLI in further studies to quantitate viral load and the ratio of replication to shedding, and therefore the pathogenicity of the virus in the lower respiratory tract. In conclusion, ... hours;Mallincrodt Diagnostica, Petten, The Netherlands), using amodified in vitro method. Ten minutes after injection of the labelled RBCs, transferrin was labelled in vivo, followingintravenous injection...