... to the functions of lost and gained domains enabled us to obtain a moredetailed view of the interplay between domain lossesand gains (Tables 3 and 4). Within an overall increase in domains involved ... specifically those lying at internal nodes corre-sponding to major branching points in the evolution of eukaryotes. Since independent evolution of the samedomain more than once is highly unlikely, ... Tetrahymena thermophila, with about 2,080and 2,190 distinct domains, respectively, while not the smallest of the genomes analyzed here, are the smallest of the free living organisms in this analysis,...