Báo cáo y học: "JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin" ppsx
Báo cáo y học: "JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin" ppsx
... purposes)Journal of InflammationOpen AccessResearchJNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittinHye Ji Park1, Hwa ... inhibited by melittin and bee venom. This finding is agreed with otherdata showing that JNK pathway is important signal in the activation of NF-κB in the processes of inflammatory reac-JNK inhibitor ... whethermelittin and bee venom inhibit NF-κB via disrupting MAPkinase signals, and thereby inhibit the inflammatory response in Raw 264.7 macrophages and in the synovio-cytes of rheumatoid arthritis patients.MethodsChemicalsRabbit...
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Báo cáo khoa học: Oxidative stress is involved in the permeabilization of the inner membrane of brain mitochondria exposed to hypoxia/reoxygenation and low micromolar Ca2+ Lorenz Schild1 and Georg Reiser2 doc
... open-ing of the mPTP. There is evidence that ADP inhibitsopening of the mPTP by occupying binding siteslocated in the inner and outer mitochondrial mem-brane [39,40]. The binding of ADP stabilizes ... of ROS, in our experiments we determined H2O2genera-tion by brain mitochondria in the presence of theseelectron donors. This is of relevance in brain, because in this tissue glucose is metabolized ... source of superoxide anion radicals is com-plex I [14]. The degree of production of ROS by the respiratory chain depends on the type of tissue, the kind of substrates driving oxidative phosphorylation(either...
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báo cáo hóa học: " Nogo receptor is involved in the adhesion of dendritic cells to myelin" ppt
... sepa-rated into a single cell sus pension by repeated pipetting and passed through a nylon mesh to remove bone and debris. Contaminating erythrocytes were removed by lysis on ice using erythrocyte lysis ... nsducingsubunits of the NgR1 complex remain to be identified.Binding of the NgR1 inhibitory complex by MAIFs leads to activation of intracellular RhoA, thereby resulting in axonaloutgrowth inhibition, ... regulated in the same way asNgR1, we went on to study the functional relevance of NgR1 expression in human DCs. This is due to previousfindings of functioning NgR1 in the absence of LINGO- 1and/ orp75NTRand...
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Báo cáo y học: "JNK suppression is essential for 17b-Estradiol inhibits prostaglandin E2-Induced uPA and MMP9 expressions and cell migration in human LoVo colon cancer cells" ppsx
... within 15 min in response to PGE2 stimulation, and was maintained upfor 24 h (Figure 3B). The findings suggested that admin-istration of PGE2 may induce the motility of humancolon cancer by inducing ... followed by the administration of PGE2 (1 μM)for 24 h, and subsequently were subjected to immuno-blotting assay to assess the effect of these inhibitors onPGE2-induced expression of uPA and MMP-9. ... periods(15 min, 30 min, 1 h, 3 h, 6 h, 12 h and 24 h), and sub-sequently measured the phosphorylation /activation of proteins by immunoblotting assay. Phosphorylation of JNK1/2 was significantly induced...
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Báo cáo y học: "Complications after spacer implantation in the treatment of hip joint infections"
... stem. For loading of the bone cement, the combination of gentamicin and vancomycin was most frequently used followed by the combination of gentamicin and teicoplanin. Data about the antibiotic ... reactions), and general complications (drain-ing sinus, pneumonia, etc.). Despite the retrospective design of our study and the limited possibility of in- terpreting these findings and their causes, ... evidence of the same organism of both the urinary tract and the hip pros-thesis [13]. Pulido et al. tried recently to identify pre-disposing factors for periprosthetic joint infections at the...
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Báo cáo y học: "A modified surgical technique in the management of eyelid burns: a case series" potx
... copy of the written consent is available for review by the Editor -in- Chief of thisjournal.AcknowledgementsWe sincerely appreciate the superb assistance of Cheltus Cheyuo MD of the Feinstein Institute ... as the use of arti-ficial tears and moist gauze covering of the eyes to pre-vent drying of the cornea. Early eyelid surgicalmanagement is critical for the protection of the cornea.Delay in ... skin for future graft contracturewhile still preserving the ability to close the eye ade-quately. We widen the grafting area by separating and loosening the musculus orbicularis oculi, gaining...
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Báo cáo y học: "Occipital peripheral nerve stimulation in the management of chronic intractable occipital neuralgia in a patient with neurofibromatosis type 1: a case report" pot
... unknown, sinc e they could interfere with the surrounding branches of the greater and les ser occi-pital nerves and create most of the symptomatologyreported by our patient. Of interest is the fact ... 5:174http://www.jmedicalcasereports.com/content/5/1/174Page 5 of 6Schwann cells, endothelial cells, fibroblasts, and a largenumber of infiltrating inflammatory mast cells [8,9].They can cause a variety of symptoms when they invadesurrounding tissues. ... divisions wit hin the substance of the trapeziousmuscle. The artery was identified by using Dopplerultrasound(Figure2).Thelocationsofthenerveandthearteryweremarkedbilaterallyontheskinwithasterile...
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Báo cáo y học: "Successful renal re-transplantation in the presence of pre-existing anti-DQ5 antibodies when there was zero mismatch at class I human leukocyte antigen A, B, & C: a case report" doc
... purposes)images. A copy of the written consent is available forreview by the Editor -in- Chief of this journal.Competing interests The authors declare that they have no competing interests.Authors' ... contributionsJH and CL wrote the manuscript and gathered the data. PS and BL performed the tissue typing and the anti-HLA anal-ysis, and helped write the manuscript. JA helped write the manuscript. ... shows the HLA typing for the recipient, as well asfor the first and second donor kidneys. The second donor and the recipient were a zero mismatch at HLA Class I A,B and C; they had two allele mismatches...
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Báo cáo y học: "Decidual soluble factors participate in the control of HIV-1 infection at the" docx
... CD14+cells are the main sources of CCL-3 and CCL-4Luminex analysis showed that CCL -3 and CCL-4 releasewas increased by R5 HIV-1 infection. To identify the source of these chemokines, freshly isolated, ... dAPC were the mainsources of CCL-3 and CCL-4 in the decidua.Decidual soluble factors can inhibit HIV-1 infectionTo examine the role of the cytokine environment in the inhibition of viral replication, ... CCL-4 and CCL-5 are known to inhibitR5 HIV-1 entry by competitively binding CCR5 [ 3]. b-chemokines might limit the number of infected cellswithin the decidua and such limit the risk of transmissionto...
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