Báo cáo khoa hoc:" Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration" doc

... 10:9http://www.jnrbm.com/content/10/1/9Page 2 of 7RESEARCH Open Access Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degenerationMarina ... intraumatic and degenerative human IVD tissue and correlated to the type of disease and the degree of degeneration (Thompson grade) . Quantification of MMP28 gene expression in human IVD tissue or in isolated ... is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration. Journal of Negative Results inBioMedicine 2011 10:9.Submit your next manuscript to BioMed...

Báo cáo khoa học: Human delta-lactoferrin is a transcription factor that enhances Skp1 (S-phase kinase-associated protein) gene expression pdf

... [18].Most of the previous studies concerning the function of the two isoforms refer to Lf, and do not discrimin-ate between the two Lf isoforms. Whereas only Lf is involved in various aspects of host ... polymorphisms in the human lactoferrin gene. Bio-chem Cell Biol 80, 17–22.43 Teng C, Gladwell W, Raphiou I & Liu E (2004) Methy-lation and expression of the lactoferrin gene in human tissues and ... concentra-tions of pcDNA-DLf was followed by RT-PCR. (B) The expression of each transcript is normalized to RPLP0 expression and is expressedas the ratio of Skp1 expression to RPLP0 expression (n...

Báo cáo khoa học: VEGF gene expression is regulated post-transcriptionally in macrophages pdf

... (data not shown). The VEGF120isoform is the most abundant PCR product. The PCRreaction is more efficient for smaller PCR products and the abundance of the smallest VEGF isoformmay reflect this. ... produce and respond to VEGF in inflamed tissues. Although an autocrinemechanism of macrophage activation is suggested,VEGFR-1 is also the target of placental growth factor[17], and the role of VEGF ... inflammatory arthritis and plaque formationin atherosclerosis. Vascular endothelial growth factor (VEGF) is an angio-genic cytokine that is produced by macrophages. To study the regulation of VEGF...

Báo cáo khóa học: ICAM-1 expression is highly NF-jB-dependent in A549 cells No role for ERK and p38 MAPK docx

... that the use of the p38 MAPK inhibitor, SB203580, only implicates the a and b isofroms of p38, as SB203580 has little or no effect onp38 c and d and it is possible that this could explaindiscrepancies ... PD098059 and U0126 on NF-jB DNAbinding and NF-jB-dependent transcription To examine the role of the p38 and the ERK MAPKpathways, we examined the effects of the p38 MAPKinhibitor, SB203580, the ... involved in the expression of ICAM-1in this system (Fig. 5).Validation of the SB203580, PD098059 and U0126in A549 cells To validate the inhibitory action of SB203580, the phos-phorylation of heat...

Báo cáo khoa học: "bcl-2 expression is not associated with survival in metastatic cutaneous melanoma: A historical cohort study" pptx

... simultane-ously, and one (2%) had the three types of metastasissince the start of metastatic disease.Results concerning the immunohistochemical expression of bcl-2 and deaths according to the three types of ... size and short follow-up time; and third, the interaction between the other members of the BCL-2 family may have neutralized the expression of bcl-2. The regulation of proapoptotic and antiapoptotic ... although the exact mechanism through which bcl-2inhibits apoptosis is not fully understood [19]. In the presence of bcl-2 overexpression, the ability of the cell to remove genetic and cell damage...

Báo cáo khoa học: Human liver mitochondrial cytochrome P450 2D6 – individual variations and implications in drug metabolism docx

... tar-geted to both the microsomal and mitochondrial frac-tions of hepatic, brain and lung tissues, and also incultured cells induced to express these proteins [9–13].These studies gave rise to the ... mitochondrial import [11,13]. Therefore, wetested the importance of the Ser135 PKA site for the mitochondrial import of CYP2D6 by mutagenesis atthis site (Fig. 5A) and in vitro import of the ... (CCCP),which disrupts the mitochondrial membrane potential, and oligomycin, which disrupts the mitochondrial ATPpool, prior to import. The level of import of WTCYP2D6 into mitochondria was...

báo cáo hóa học: " Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors" ppt

... interpretation of the results and to writing. W.S.T.G. contributed to the design of the study, interpretation of the results, and writing. S.W.B. made essential contributions to the design of the study and ... 60 N.A. Figure 4 9DISCUSSION The neuroinflammagenic potential of IL-1β is shown here through its induction of synthesis of itself and other proinflammatory cytokines including TNF, IL-1α, ... Inheritance of the particular isoform of ApoE encoded by the ε4 variant of the APOE gene confers significant risk for precocious development of AD [4, 5]: those with two copies of the ε4 allele of APOE...

báo cáo khoa học: "A nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma" ppt

... yzu@tmhs.org1Department of Pathology, the Methodist Hospital and the MethodistHospital Research Institute, 6565 Fannin street, Houston, TX 77030, USAFull list of author information is available at the end of the ... 10 of 12negatively-charged nature of both the siRNA and apta-mer that have complexed with the PEI-citrate nanocore.Further, the potential of the nanocomplex dropped to -25 ± 0.9 mV in the ... microscopy to visualize the DAPI-stained nuclei (blue) and the Cy5 reporter signal of the nanocomplex (red). Merged images of the DAPI-stained nuclei and Cy5 reportersignal indicate the intracellular...

báo cáo khoa học:" A ‘short walk’ is longer before radiotherapy than afterwards: a qualitative study questioning the baseline and follow-up design" potx

... comprehension and inter-pretation of the question; b) recall of relevant informa-tion; and c) combination of the retrieved information.TheTourangeaumodeldoesnotincludetheuseofstandards of comparison, ... whether the content of each distinct cognitive process underlying QoL appraisal is (dis)similar over time and whether patterns of (dis)similarity can be discerned across and within patients and/ oritems.Methods: ... could not discernpatterns of (dis)similarity since the content of each of the cognitive processes differed across and wit hinpatients and/ or items. Thus, the assumption of consis-tency in the...

Báo cáo khoa học: "TENSE GENERATION IN AN INTELLIGENT TUTOR FOR FOREIGN LANGUAGE TEACHING: SOME ISSUES IN THE DESIGN OF THE VERB EXPERT" pot

... identify the errors, if any, present in the former and to formulate some hypotheses about their causes. On the basis of these hypotheses, the Tutor selects the next exercise which will test the ... the Tutor will possibly switch to other topics. 4. THE DOMAIN EXPERT The Domain Expert is devoted to generate the fight answers for the exercises proposed to the student. Usually, exercises ... open item of the exercise in order to correctly describe the status of the world the sentence is intended to represent, and ii) to appropriately conjugate the verb according to the chosen...

Xem thêm