Báo cáo khoa hoc:" The CTGF -945GC polymorphism is not associated with plasma CTGF and does not predict nephropathy or outcome in type 1 diabetes" pptx
Báo cáo khoa hoc:" The CTGF -945GC polymorphism is not associated with plasma CTGF and does not predict nephropathy or outcome in type 1 diabetes" pptx
... 37:3 51- 358.doi :10 .11 86 /14 77-57 51- 10-4Cite this article as: Dendooven et al.: The CTGF -945GC polymorphism is not associated with plasma CTGF and does not predict nephropathy or outcome in type 1 ... investigated whether the -945GC polymorphism is associated with plasma CTGF level and outcome in type 1 diabetes. The study cohort consisted of 448 diabetic nephropathy patients and 419 normoa lbuminuric ... 10 :4http://www.jnrbm.com/content /10 /1/ 4Page 2 of 4BRIE F REP O R T Open Access The CTGF -945GC polymorphism is not associated with plasma CTGF and does not predict nephropathy or outcome in type 1 diabetesAmélie...
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Tài liệu Báo cáo khoa học: The resident endoplasmic reticulum protein, BAP31, associates with c-actin and myosin B heavy chain Analysis by capillary liquid chromatography microelectrospray tandem MS ppt
... N-terminal fragment is predicted toform three transmembrane domains in which the shorthydrophilic N terminus and a 37 amino acid loop face the lumen of the ER. The remaining 13 -kDa domain, termin-ated ... methodsPlasmids and cloningcDNA encoding human BAP 31 with the Flag peptideepitope sequence inserted between the codons for aminoacids 242 and 243 was incorporated into the pcDNA3 .1 expression vector as ... preparation forblebbing. In this context, the expression of the caspase-resistant BAP 31 in KB epithelial cells subjected to apoptosisafter Fas stimulation initially maintained a normal c-actindistribution...
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Báo cáo khoa học: The equinatoxin N-terminus is transferred across planar lipid membranes and helps to stabilize the transmembrane pore pot
... protein isolated from the sea anemone Acti-nia equina. It is a member of the actinoporins, a family of eukaryotic pore-forming toxins with a unique mechanism of pore formation. Equinatoxin II is ... about 1 when the amino acid side chain is not facing the lumen of the pore, as was observed for most of the mutants in region 10 –28 of EqtII [24]. For the mutantsexposed to the pore lumen, this ... acids in the final pore The change in the fixed charge distribution through the pore affects the pore conductance [30]. Therefore,it can be used for determining the residues exposed to the lumen and the...
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Tài liệu Báo cáo khoa học:Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau ppt
... accepted 16 June 2 011 )doi :10 .11 11/ j .17 42-4658.2 011 .08 218 .xRecent reports have demonstrated that interactions between the microtu-bule -associated protein tau and the nonreceptor tyrosine kinase ... tau [17 19 ], and tau alsointeracts with Fyn via its Src homology (SH)3 domain[20, 21] . The SH3 domain of Fyn binds to proline-richmotifs within the sequence PXXP in interacting pro-teins. ... are present in the proline-richdomain of the longest isoform of tau in the humancentral nervous system (CNS). Two distinct PXXPmotifs in tau, residing within residues 213 – 219 and 233–236,...
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Tài liệu Báo cáo khoa học: The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding pptx
... blotting.proBMP-2ABCBMP-2P-Smad 1/ 5/8Smad 1 P-p38Actin0 15 30 60 12 0 15 30 60 12 0 minTime (min)0 20 40 60 80 10 0 12 0 14 0Time (min)0 2040608 010 012 014 0020406080 10 0 12 0Relative intensity (%)Relative intensity ... of the pro-peptide and BMP-9can bind to the type I receptor Alk1 [17 ], the latency- associated polypeptide of TGFb inhibits the interac-tion of TGFb isoforms with type II and III receptors[40]. ... ± 1. 8 · 10 )9m) wasobtained (Fig. 2B and Table 1) . This result shows that the pro-peptide moiety does not interfere with bindingof the mature part to BMPR-IA. As the BMPR-IAbinding site for...
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Tài liệu Báo cáo khoa học: The cellulosomes from Clostridium cellulolyticum Identification of new components and synergies between complexes ppt
... 89.0cPutative xylanase This study 12 11 0588 916 S-GH10-doc 44.3 17 ⁄ 37 36.0 13 5.0cXylanase Xyn10A 9 14 22092 819 9 S-GH 11- doc 29.6 5 ⁄ 4 19 .0 71. 0cXylanase Xyn11B This studyF5 ⁄ F62 11 0588925 S-GH9-CBM3-doc ... abundant in F1, were identified asxylanases belonging to GH family 10 (protein 12 ),named Xyn10A [14 ], and to GH family 11 (protein 14 ), renamed Xyn11B. In addition a hypotheticalxylanase (protein ... numbered 1 14 (Fig. 2). Fraction 1 contained high amounts of proteins 6, 9, 12 and 14 ,whereas proteins 1, 2, 3, 4, 5, 7, 8, 10 , 11 and 13 werepresent in fractions F5 and F6 but absent or barelydetectable...
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Tài liệu Báo cáo khoa học: "The QuALiM Question Answering Demo: Supplementing Answers with Paragraphs drawn from Wikipedia" ppt
... updated, whereas the AQUAINT corpus remains static and thus con-tains a lot of outdated information.Another advantage of Wikipedia is that the in- formation contained is much more structured. ... intentionbehind this mode of presentation is to prominentlydisplay the piece of information the user is most in- terested in, but also to present context information and to furthermore provide ... article with title “Franz Kafka” and to expect the answer in the text on that page. For the question “Who invented the automobile?” on the other hand, it is more reasonable to search the information...
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Báo cáo khoa học: The bioactive dipeptide anserine is transported by human proton-coupled peptide transporters doc
... December2009)doi :10 .11 11/ j .17 42-4658.2009.07528.x The bioactive dipeptide derivative anserine (b-alanyl -1- N-methyl-l-histidine) is absorbed from the human diet in intact form at the intestinal epithelium. The ... stronghPEPT1-specific inward transport currents were recorded for Gly-Sar,anserine and carnosine, but not for glycine. We conclude that anserine and carnosine interact with the human intestinal peptide ... transporter and aretransported by hPEPT1 in an active, electrogenic H+symport. As PEPT1 is the predominant transport system for di- and tripeptides at the intestinalepithelium, this transporter...
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Báo cáo khoa học: The retinoid-X receptor ortholog, ultraspiracle, binds with nanomolar affinity to an endogenous morphogenetic ligand pptx
... into the ligand-binding pocket cavity (and not interacting with secondary recep-tor structures or extending to the receptor surface to interact with coactiva-tors, corepressors or receptor dimer ... which the free ligand concentration is adjusted for the portion of ligand removed from solutionby binding to the receptor [ 61] . Kdfor the interaction ofUSP with each ligand (or Ki in the cases ... provided for physiological testing without indicatingwhich sample was the 10 ,11 -epoxide.BisepoxyJH III was synthesized using the 10 ,11 -mono-epoxide isomer of JH III as the starting material. Synthesiswas...
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Báo cáo khoa học: The optimization of protein secondary structure determination with infrared and circular dichroism spectra docx
... deter-mining the tyrosine band a rea ratios at 15 18 cm 1 ,andthenusing this as the scaling factor for subtracting the originalspectra [40]. Due to low tyrosine s ignal, the proteins BTE,FTN, ... method for protein spectra, atleast w ithin the proteins of the RaSP50 b asis set. The findingthat the Mahalanobis distance does not correlate with analysis accuracy for the RaSP50 set has importantconsequences ... either baseline-corrected to bringboth endpoints to zero, or if baseline-correction was not used, the first value in the band was subtracted from allother data points in order to bring the minimum...
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