Báo cáo y học: " Part I, Patient perspective: activating patients to engage their providers in the use of evidencebased medicine: a qualitative evaluation of the VA Project to Implement Diuretics (VAPID)" ppsx

... value to clinical administration leaderswho are responsible for improving the quality of care. The patient activation strategy was acceptable to most patients, served as a to ol to engage patients ... appear to be systematic.Summary The primary purpose of this study was to evaluate the acceptability of a patient- activated intervention from the patients perspective. Patients along a spectrum of ... to engage their providers in the use of evidence-based medicine: a qualitative evaluation of the VA Project to Implement Diuretics (VAPID)Stacey A Pilling1, Monica B Williams1, Rachel Horner Brackett1,...

báo cáo khoa học: " Part I, Patient perspective: activating patients to engage their providers in the use of evidencebased medicine: a qualitative evaluation of the VA Project to Implement Diuretics (VAPID)" pps

... perspective: activating patients to engage their providers in the use of evidence-based medicine: a qualitative evaluation of the VA Project to Implement Diuretics (VAPID). Implementation Science ... Additionally, many patients specifiedethical motivations for participating in the study and forbring ing in the letter for discussion. For sev eral patients it was their way of ‘paying back’ the ... limitations of this study. First, the study was restricted to a sample of predominatel y whitemale VA patients. The findings may be unique to the VA, as many veterans appear to exhibit a sense of obli-gation...

Báo cáo y học: "Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis" doc

... Eva Balaziova1and Liliana R Sedova31Laboratory of Cancer Cell Biology of the 1stFaculty of Medicine, Charles University, Prague and the Institute of Physiology, Academy of Sciences,Prague, ... cell activation to extravasation, andfrom cartilage breakdown to the release of chemokines andcytokines that attract new T cells and monocytes, therebyincreasing the inflammatory response and ... deaminase (ADA)-binding protein.Because the anti-folate treatments for RA, exemplified bymethotrexate, mediate their anti-inflammatory effects in part through locally increasing extracellular adenosine...

Báo cáo y học: " TGF β-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7" pps

... factors favoring the catabolic side is very likely involved in the pathological fea-tures of OA.Currently, many attempts are being made to repair the carti-lage that has been damaged in OA. ... contributionsENBD participated in the animal experiments and immunohis-tochemistry, carried out the histological measurements, ana-lyzed the data, and drafted the manuscript. ELV participated in the animal ... factor beta: studies in anatomically intact cartilage in vitro and in vivo. Ann Rheum Dis1993, 52:185-191.15. Chandrasekhar S, Harvey AK: Transforming growth factor-betais a potent inhibitor...

Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" ppt

... 7:33http://www.journal-inflammation.com/content/7/1/33Page 2 of 7[2,7]. These are used to manipulate the basal transcrip-tional machinery and the chromatin structure throughaltering their acetylation and methylation status andthereby regulating ... GAPDH(Abcam).Statistical AnalysisData was analysed by 1 way ANOVA to determine statis-tical significant variance between the groups for eachendpoint assessed. Statistical significance betweengroups ... HDAC-2 antibody (Santa Cruz Biotechnology, CA,USA); mSin 3a antibody (Abcam, Cambridge, UK); Mi2α/β antibody (Austral Biotechnology, San Ramon, CA,USA); Lamin A/ C antibody (Santa Cruz); GAPDH(Abcam).Statistical...

Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" pdf

... Biotechnology, San Ramon, CA,USA); Lamin A/ C antibody (Santa Cruz); GAPDH(Abcam).Statistical AnalysisData was analysed by 1 way ANOVA to determine statis-tical significant variance between the groups ... 7:33http://www.journal-inflammation.com/content/7/1/33Page 2 of 7[2,7]. These are used to manipulate the basal transcrip-tional machinery and the chromatin structure throughaltering their acetylation and ... manuscript. IMA and PAK conceived of the study, participated in its design and coordination and helped in prepara-tion of the manuscript. All authors read and approved the final manuscript.AcknowledgementsThis...

Báo cáo y học: "Part II, Provider perspectives: should patients be activated to request evidence-based medicine? a qualitative study of the VA project to implement diuretics (VAPID)" ppsx

... Part I, Patient Perspective: Activating patients to engage their providers in the use of evidence-based medicine: a qualitative evaluation of the VA Project to Implement Diuretics (VAPID). Implement ... several pointed outthat patients were not accusatory or threatening in anyway. Concerns about activating the wrong patients reinforces that patients targeted for activation in futureinterventions ... distra cter issue that th e patients want to talkabout. They don’tfrequentlywanttotalkaboutormention a chronic asymptomatic disease. They have a rash on their elbow and a little ringing in their ear...

Báo cáo y học: "β Treatment with recombinant interferon-β reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis" ppt

... volunteers. J Interferon Cytokine Res 2000, 20:857-866.28. Miyazaki T, Katagiri H, Kanegae Y, Takayanagi H, Sawada Y, Yamamoto A, Pando MP, Asano T, Verma IM, Oda H, NakamuraK, Tanaka S: Reciprocal role ... monocyteactivation. Our data demonstrated statistically significantmodulation of proinflammatory and anti-inflammatory cyto-kine production in animals treated with IFN-β. We found a statistically ... into the mechanism by which IFN-β therapy exerts its beneficial effects, we examinedcytokine expression at the site of inflammation. Severalproinflammatory cytokines play a crucial role in the Available...

Báo cáo y học: "Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity" pdf

... experimental animals. The amounts of citrullinated proteins and the enzyme PAD4 arecorrelated with severity of inflammation and are not detect-able in healthy joints. The study also reveals that the ... healthy joints, and that the appearance and amounts in arthritic joints of experimentalanimals are correlated with the severity of inflammation.Introduction The chronic inflammatory joint disease ... Jolivet-Rey-naud C, et al.: The epitopes targeted by the rheumatoid arthri-tis-associated antifilaggrin autoantibodies areposttranslationally generated on various sites of (pro)filaggrinby deimination...

Báo cáo y học: " Bronchoalveoloar lavage fluid cytokines and chemokines as markers and predictors for the outcome of interstitial lung disease in systemic sclerosis patients" pps

... predictive value of cytokinesand chemokines was evaluated. We have identified keycytokines that appear to be associated with lung fibrosis andthat may predict worsening of ILD in SSc patients. Materials ... parametersselected by univariate analyses with P values less than 0.1. In a second multivariate analysis, only BALF cytokines werestudied. Multiple samples from one patient were accordinglyweighed for analysis. ... BALFmanipulation that could influence the stability of cytokines. Byusing this technique, we observed abnormalities in a broadrange of cytokines and chemokines, probably reflecting the Table...

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