Báo cáo y học: "Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in Cystic Fibrosis cells" ppsx
... pretreatment results in an inhibition of inflammatory signaling in
cells with CF defects.
Production of IL-8 and other pro-inflammatory cytokines is also governed by
mechanisms regulating in their mRNA ... extracellular-regulated protein kinase (ERK) cascades are active by
phosphorylation through dual specificity MAPK kinases (MKK) and may all contribute
to IL-8 expre...
... reported that indices related to
hyperinflation, such as the inspiratory capacity (IC), are more closely related to exercise
tolerance and dyspnea than the forced expiratory volume in 1 second ... static lung hyperinflation estimated by the inspiratory
capacity to- total lung capacity (IC/TLC) ratio is a predictor of all-cause and respiratory
mortality in patients with COPD,...
... Epac,
may instead activate a tyrosine phosphatase which
results in the observed decrease in both basal and
CSF-1-induced tyrosine phosphorylation.
In contrast to the data for EGFR-dependent tyro-
sine ... monocyte DNA synthesis by colony-stimulating
factors, cytokines, and cyclic adenosine monophosphate.
Blood 79, 1972–1981.
9 Vairo G, Argyriou S, Bordun AM, Whitty G & Hamil...
... bone
marrow cavity in chronic inflammatory arthritis.
Introduction
TNF is a clinically validated etiological factor in inflammatory-
erosive arthritis and is known to synergize with RANKL and
macrophage ... in inflammatory
osteolysis. Arthritis Res Ther 2006, 8:201.
2. Boyce BF, Schwarz EM, Xing L: Osteoclast precursors:
cytokine-stimulated immunomodulators of inflammatory bone
di...
... F, Ficheux H, Pujol JP: Rhein
inhibits interleukin-1 beta-induced activation of MEK /ERK
pathway and DNA binding of NF-kappa B and AP-1 in chondro-
cytes cultured in hypoxia: a potential mechanism ... growth
factors, cytokines, proteases, and inflammatory mediators. The
levels of alkaline phosphatase, osteocalcin, type I collagen,
interleukin (IL)-6, transforming growth factor-...
... signals in macrophages [7]. The two pro-
inflammatory enzymes, induciblenitricoxidesynthase
(iNOS) and cyclooxygenase-2 (COX-2), which can be
induced by LPS or cytokines, are found to work in concert
in ... the production of
inflammatory cytokines, chemokines, and proinflamma-
tory enzymes (e.g. iNOS and COX-2) [38-40]. The pro-
moter of the iNOS and COX-2 genes are know...
... expres-
sion in joints affected by AIA on Day 1. Abundant stain-
ing was detected in the synovial lining layer, joint exudate
and focal areas of synovial infiltration; it was comparable
in WT and IFN-γ-/- ... IL-1β induced MMP secretion by RA FLS
In RA cartilage damage is predominantly mediated by the
MMPs; most notably MMP-1, -13 and -3 [19]. Their syn-
thesis is driven by pr...
... play in allergic, asthmatic, and
inflammatory responses, conditions caused by the pro-
duction of mediators and select inflammatory cytokines
[1,2].
Interleukin-6 (IL-6), interleukin-8 (IL-8) , and ... and
autoimmune diseases. Human mast cells play an integral
role in the inflammatory response by accumulating at
sites of inflammation and mediating the production of
inflammatory...
... prepared using heated processing
conditions to substantially inactivate hemagglutinat-
ing activity (HA) and trypsin inhibiting activity (TIA)
while preserving alpha-amylase inhibiting ability. ... to follow the
nutritionist’s recommendations. The candidates were
entered into a 2-week single-blinded, run -in to en-
rollment and randomization. Subjects in this run -in
period...