báo cáo khoa học: " Female heterozygotes for the hypomorphic R40H mutation can have ornithine transcarbamylase deficiency and present in early adolescence: a case report and review of the literature" docx

... this article as: Pinner et al.: Female heterozygotes for the hypomorphic R40H mutation can have ornithine transcarbamylase deficiency and present in early adolescence: a case report and review of ... Access Female heterozygotes for the hypomorphic R40H mutation can have ornithine transcarbamylase deficiency and present in early adolescence: a case report and review of the literatureJason R Pinner1*, ... Uematsu A, Tanaka K, Kiwaki K, Endo F, Matsuda I,Nagasaka H, Furusho K: X-inactivation pattern in the liver of a manifesting female with ornithine transcarbamylase (OTC) deficiency. Clinical...

báo cáo khoa học: " Knowledge transfer for the management of dementia: a cluster-randomised trial of blended learning in general practice" potx

... creditpoints gained for attendance of the QC meetings and in case of blended learning for the online modules.InterventionAllGPsinoneQCwererandomisedasaclustertostudy arm A (blended learning–online modules ... MA,Butzlaff M: [Multimodal training of general practitioners–evaluation and knowledge increase within the framework of the dementiamanagement initiative in general medicine (IDA)]. Z Arztl FortbildQualitatssich ... conceived and developed this survey and drafted the manuscript. Hecollected and collated the data and assisted with statistical analysis. HMperformed the statistical analysis and helped to draft the...

Báo cáo khoa học: "Medical treatment for the terminally ill: the ‘risk of unacceptable badness’"

... toemphasize what Streat and coworkers [15] termed, the largerisk of unacceptable badness’, rather than a vanishingly smallpotential for benefit.There are far worse things than death, and many of ... unsuccessful in achieving a stated goal. Therefore, if a patient in a progressive,inevitable death spiral is placed on mechanical ventilation,it is not technically futile if vital signs are sustained,however ... investigatorscannot find these patients. Accordingly, some families feelthat if life support systems can maintain vital signs for a day or a week, then ‘suspended animation’ should bepossible indefinitely,...

Tài liệu Báo cáo khoa học: "Unsupervised Search for The Optimal Segmentation for Statistical Machine Translation" doc

... op-timal degree of segmentation might decrease as the amount of training data increases (Lee, 2004;Habash and Sadat, 2006). This brings into ques-tion: For the particular language pair and trainingcorpus ... (2004) and in the scheme“EN” of Habash and Sadat (2006). In Lee (2004), the goal is to match the lexical granularities of the two languages by starting with a ﬁne-grained seg-mentation of the Arabic ... decomposition and com-31Count Morfessor Morfessor-bi English Gloss7 anahtar anahtar (the) key6 anahtar + ımı anahtar + ımı my key (ACC.)5 anahtarla anahtar + la with (the) key4 anahtarı anahtar +...

Tài liệu Báo cáo khoa học: A role for the intersubunit disulﬁdes of seminal RNase in the mechanism of its antitumor action docx

... sulfhydryls.These results indicate that the intersubunit disulﬁde bonds of BS-RNase have a key role in the mechanism of antitumour action of the enzyme.Materials and methodsMaterialsIodoacetic acid ... MSSAE was detached by high salt from SVT2 cells atincreasing time intervals. In the insert, autoradiographic scans of the SDS/PAGE runs. D and M mark the electrophoretic mobilities of BS-RNase ... SVT2 cells. The incubation was performed (A) in the absence of iodoacetamide (IAM), (B) in the presence of 10 mMIAM, or (C) of 50 mMIAM. D and M mark the elution volumes of BS-RNase and monomeric...

Báo cáo khoa học: New evidence for the role of calcium in the glycosidase reaction of GH43 arabinanases pot

... located in blades IV and V and the C-terminal domain or between the hair-pin that joins blades IV and V and the C-terminaldomain (Fig. 1 and Table S1). The apolar interactions in the interface ... a- l-1,2-, a- l-1,3- and a- l-1,5-arabinosyl residues from various oligosac-charides and polysaccharides, including arabinan, ara-binoxylan and arabinogalactan [6,7]. ABNs attack the glycosidic bonds of ... structure of BsArb43B comprisesall 443 amino acids of the mature protein. BsArb43Bconsists of two domains, an N-terminal catalyticdomain (Ala28–Tyr367) and a C-terminal domain(Ala368–Ala470). The...

Báo cáo khoa học: Structural basis for the erythro-stereospeciﬁcity of the L-arginine oxygenase VioC in viomycin biosynthesis docx

... l-arginine, but alsotolerates l-homoarginine and l-canavanine (Fig. 3A, Table 1). These ﬁndings can be explained by the coor-dination of l-arginine in the active site of VioC(Figs 4, 5 and ... C-terminal helical subdomain. Accordingly, VioC exertsbroadened substrate speciﬁcity by accepting the analogs l-homoarginine and l-canavanine for Cb-hydroxylation.Abbreviations A- domain, adenylation ... sub-strate, which enforces a gauche(–) conformer for v1instead of the transconformers observed for the asparagine oxygenase AsnO and other mem-bers of the clavaminic acid synthase-like superfamily....

Báo cáo khoa học: "Semantic Retrieval for the Accurate Identiﬁcation of Relational Concepts in Massive Textbases" ppt

... the follow-ing experiments. Words in italics indicate a class of words: “something” indicates that any word can appear, and disease indicates that any dis-ease expression can appear. These queries ... ontologydatabases, deep parsers, and search algorithms for structured data are introduced.2.1 Ontology databasesOntology databases are collections of words and phrases in speciﬁc domains. Such databases ... an-cestor/descendant relations in XML. For example, A > B” indicates that A is an ancestor of B. In [tag] Region covered with “<tag>” A > B A containing B A >> B A containing B (A is not...

Báo cáo khoa học: "SOFTWARE TOOLS FOR THE ENVIRONMENT OF A COMPUTER AIDED TRANSLATION SYSTEM" pptx

... can also contain definitions, examples, and equivalents in several languages : it is totally free (and uncontrolled). Finally, the file R is the final translation of the original text realized ... reassemble and clearly distinguish certain information contained in a linguistic application data base. VISULEX is intended to facilitate the comprehension and development of coded dictionaries ... insert into the revision file a part of another file, make permutations or transpositions of several parts of a file, and receive suggestions for the translation of a word displayed in a win-...

Báo cáo khoa học: Structural basis for the recognition of complex-type biantennary oligosaccharides by Pterocarpus angolensis lectin ppt

... explain thermodynamic data for the binding of Mana(1–2)Man and GlcNAcb(1–2)Man to con A [30], and was later confirmed for Mana(1–2)Man byX-ray crystallography [31]. In the case of PAL such a sliding ... there is a smallincrease in affinity and the additional carbohy-drate:protein contacts are mirrored by a more favora-ble enthalpy of binding.On the other hand, binding of N-acetylglucosamineto ... GlcNAc in the )1 subsite of PAL is energetically favorable and contri-butes significantly to the higher affinity of PAL for the pentasaccharide M592 (Table 3). In the case of con A on the other hand,...

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