... MR, Winter P & SaraivaMJ (1997) Screening and biochemical characterization of transthyretin variants in the Portuguese population.Hum Mutat 9, 226–233.8 Nakazato M, Kangawa K, Minamino ... on the transthyretin (prealbumin) -methionine-30 variant.J Clin Invest 76, 2171–2177.50 Nakazato M, Kurihara T, Matsukura S, Kangawa K& Matsuo H (1986) Diagnostic radioimmunoassay forfamilial ... The overall 3Dstructure of TTR has been maintained over vertebrateevolution, and, notably, the amino-acid sequences in the thyroxine-binding site are identical in all speciesexamined to date...