... JA: Kinase mutations and imatinibresponse in patients with metastatic gastrointestinal stro-mal tumor. J Clin Oncol 2003, 21:4342-4349.2. Hirota S, Ohashi A, Nishida T, Isozaki K, Kinoshita ... "National Institute for Infectious Diseases – L. Spallanzani" IRCCS, Rome, ItalyEmail: Christian Franzini - chrisslrfra@libero.it; Luciano Alessandri - luciano.alessandri@ausl.re.it; Irene ... citation purposes)protein, having a gain-of-function mutation in the regula-tory juxtamembrane domain of the c-kit gene or an acti-vating mutation in another class III receptor tyrosinekinase...