báo cáo khoa học: " Skin permeation mechanism and bioavailability enhancement of celecoxib from transdermally applied nanoemulsion" potx

... 1 of 11(page number not for citation purposes)Journal of NanobiotechnologyOpen AccessResearch Skin permeation mechanism and bioavailability enhancement of celecoxib from transdermally applied ... oral bioavailability of around 40% (Capsule). Therefore the aim of the present investigation was toassess the skin permeation mechanism and bioavailability of celecoxib by transdermally applied nanoemulsion ... delivery of zidovu-dine: effect of terpenes and their mechanism of action. J Con-trol Rel 2004, 95:367-379.21. Cole L, Heard C: Skin permeation enhancement potential of aloe vera and a proposed mechanism...

Báo cáo khoa học: Puriﬁcation, characterization and molecular cloning of tyrosinase from the cephalopod mollusk, Illex argentinus docx

... dialyzedsolution of AS60 (300 mL) obtained from 100 g of defattedink powder contained 2.9 g of protein, 0.29 g of hexose,0.25 g of uronic acid, 0.12 g of methylpentose and 5400units of tyrosinase ... properties of the squid tyrosinaseEﬀects of pH and temperature on stability and acti-vity. As ST94 and ST94t showed the identical results onpH- and temperature-effects, we describe the data of ST94t ... These estimates of the molecular mass of ST94 were supported by the result of gel permeation HPLC(Fig. 3). There was a minor band between 140 and 232 kDain the native-PAGE of Fig. 2A (lane...

Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx

... thestructures of PSs from E. coli and M. tuberculosis.Structural analysesAnalysis of the sites of substrate binding from NMR data, and structural comparison of the E. coli, M. tuberculosis and A. ... 164° and )169° in the A-chain and B-chain of nPS, respectively. The v1torsion angle forAsp35 changes from ) 75.20° to )171.65° and )89.25°in the A-chain and B-chain of nPS, and in the case of His37, ... shift (p.p.m.) of residues of nPS upon binding to (A)D-pantoate as a function of sequence, and (B)D-pantoate and ATP as a function of sequence.Residues that showed a deviation of more than 0.03...

Báo cáo khoa học: nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modiﬁcations pot

... dorsal surface and into thegut of the amphibian [1–4]. A number of different types of bioactive peptides have been identiﬁed from the glandular skin secretions of Australian anurans of the Litoria ... antibiotic peptidein the secretion of the skin glands of L. citropa [9]. It is one of the most potent membrane-active antibiotic peptidesisolated from amphibians and is particularly effectiveagainst ... of Adelaide, South Australia, AustraliaA large number of bioactive peptides have been isolated from amphibian skin secretions. These peptides have avariety of actions including antibiotic and...

Báo cáo khoa học: Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase pptx

... state.The actual and detailed mechanism of GC activationby ANP, namely the signal transduction mechanism, must await determination of NPRA’s GCD structure and ultimately the structure of full-length ... allowsdetermination of the native structures in the absence of crystal contacts and in solution conditions closer tothose of the native environment. The three-dimensionalreconstructions of the apo-ECD dimer and ... present an overview of the structure, possible chloride-mediated regula-tion and signaling mechanism of NPRA and other receptor GCs. Earlier,we determined the crystal structures of the NPRA extracellular...

Báo cáo khoa học: "Skin Sparing Mastectomy and Immediate Breast Reconstruction (SSMIR) for early breast cancer: Eight years single institution experience" ppsx

... diagnosis of breast cancer and more use of ster-eotactic technique in diagnosis of breast carcinoma. Allthe margins of mastectomy were negative and the rate of malignant involvement of nipple-areole ... died because of cardiac events.DiscussionRising popularity of skin sparing mastectomy is due tobetter understanding of tumor biology and pattern of recurrence. Data showed that most of patients ... before admission. Skin sparing mastectomy has been classified according tothe type of surgical incision, the amount of skin to beremoved, and the pattern of skin removal. The choice of incision was...

Tài liệu Báo cáo khoa học: Processing, catalytic activity and crystal structures of kumamolisin-As with an engineered active site pptx

... 7.0 and 4 °C for 6 h, followed by SDS ⁄ PAGE. The rate of ligation was estimated from percentageintensity of the band of the 57-kDa protein in a total of intensities of the 57-kDa, 38-kDa and ... surrogate of the c-carboxy group of Glu78 of the wild-type enzyme. Moreover, a comparison of log kcatvs. pH proﬁles of the E78H and E78H ⁄ D164Nmutants provides clues to understanding the ... switch of pH-dependence of the kcatvalue upon the E78H ⁄ D164N substitution suggeststhat the observed pKavalue (5.9) of kcat of the wild-type must arise from titration of Glu78 and ⁄ orAsp164....

Báo cáo khoa học: Alternative splicing: good and bad effects of translationally silent substitutions pdf

... splicing.A variety of tools are available to us for this purpose and further investigation of these sequence variants willnot only further our understanding of the splicing mechanism and improve clinical ... (mouse–rat and human–dog) [10]. This analysis showed a strong puri-fying selection at silent sites in a critical region of thisgene [10], spanning the 3¢ end of exon 10 and the 5¢end of exon ... the detection of both lower Ka and Ksin one region is probably an index of splicingconstraint rather than the detection of Ka⁄ Kspeaks,which may be due to a high Karatio and not to selec-tive...

Báo cáo khoa học: Protein–protein interactions and selection: generation of molecule-binding proteins on the basis of tertiary structural information potx

... BC, DE and FG loopsY/A/S/D libraryin all the CDR loops[ref 38]Y/S libraryin all the CDRs of heavy chain and CDR3 of light chain[ref 39]10FN3Randomization in CDR loops of heavy and light ... VEGFwere selected from a restricted library constructed from only Tyr, Ser, Asp, and Ala, and X-ray structuralanalysis demonstrated the importance of Tyr residues[38]. The construction of more restricted ... scaffold proteins. In the case of single-chainFvs and Fabs, artiﬁcial libraries of CDR loops havebeen constructed from synthetic DNA fragments withrandomized sequences and lengths. The ﬁrst attemptwith...

Báo cáo khoa học "ADIABATIC TEMPERATURE RISE AND REACTION RATE OF MASS STRUCTURE IN LOTTE CENTER HANOI PROJECT " pptx

... analysis of the total cross section of mat foundation (b) Stress dispersion of the total cross section of mat foundation during and after curing (c) TCI of the total cross section of mat ... According to the table applied curing method can prevent from harmful cracks, recording TCI of 1.03 to 1.19. Table 3. The results of thermal stress by temperature of concrete and curing The analyzed ... same by cooling from low temperature in the air while inside of volume expands by high temperature from accumulating hydration heat. That is, difference between inside and surface of structure...

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