... feeding behavior and body weight. ACC, acetyl-CoA car-boxylase; AMPK, 5¢ AMP kinase; CPT, carnitine palmitoyltransfer-ase; FAS, fatty acid synthase; MCD, malonyl-CoA decarboxylase;OAA, oxaloacetate; ... intracerebroventricular administration of fatty acid synthase (FAS) inhibitors causes a dra-matic decrease in food intake and body weight, con-comitant with an increase in the level of its substrate,malonyl-CoA ... increase in malonyl-CoA promotes a decrease in neuropeptide Y and agouti related peptide in hypo-thalamic malonyl-CoA while promoting an increase in proopiomelanocortin and cocaine and amphetamineregulated...