... protein at aggrecanase clea-vage sites [10]. In the case of versican, it appears thatthe catabolism may involve the action of other matrixproteinases as well as that of aggrecanase [10]. It hasbeen ... heparin In order to determine the rate of intracellular degradation of 35S-labeled small proteoglycans, bovine tendon from a single metacarpophalangeal joint was incubated with [35S]sulfate ... Corporation, Bedford, MA, USA, andAmplify was from Amersham Pharmacia (Amersham,Buckinghamshire, UK). Heparin (from porcine intestinalmucosa) was purchased from Celsus Laboratories (Cincin-nati,...