báo cáo khoa học: "The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1" docx
báo cáo khoa học: "The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1" docx
... Open AccessThe anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP9 0A and HSP90B1Saad Z Usmani1*, Robert D Bona2, Gabriela Chiosis3, Zihai ... cytosolic HSP90 (HSP90AA1), the ERparalogue gp96 (HSP90B1) and the mitochondrial member TRAP1 (HSP90L). We evaluated the in vitro anti-tumor activity and mechanism of action of PU-H71, a novel purine ... evaluated the in vitro anti-myeloma activity of PU-H71, a novel purine scaffold HSP90 inhibitor. Wealso determined if the anti-tumor activity of HSP90 inhibitors is achieved via targeting both...
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Tài liệu Báo cáo khoa học: The phosphatase activity of the isolated H4-H5 loop of Na+/K+ ATPase resides outside its ATP binding site docx
... protein and its truncation products. K+activated p-nitrophenyl-phosphatase as a partial activity of Na+/K+ATPase wasmeasured as described previously [17]. S tatistical analysis of the comparison ... plasma membranes of mammalian cells. The enzyme is a heterodimer of a 100 kDa catalytic subunit and a heavily glycosylated b subunit of about 55 kDa [1–3].Ouabain, recently recognized as a m ammalian ... overallNa+/K+ATPase [51], is puzzling. A comparison of theamino acid sequences between N377 and L414 for various a subunit isoforms of Na+/K+ATPase and H+/K+ATPaserevealed t hat...
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Báo cáo khoa học: The antibiotic activity of cationic linear amphipathic peptides: lessons from the action of leucine/lysine copolymers on bacteria of the class Mollicutes doc
... also for theantimicrobial activity of these peptides. In this work, wehave taken advantage of the fact that bacteria of the classMollicutes are devoid of an outer membrane and of a cellwall, ... of membranedepolarization and the delay necessary to reach a steady-state level of depolarization. Actually, 0.1 lMmelittintotally depolarized the A. laidlawii membrane within5minandthatofS. ... accumulation of Fig. 5. Graphical illustration of the effects on antibacterial activity of thelength of alpha-amphi series peptides vs. A. laidlawii membrane thick-ness. Antibacterial activities are...
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Báo cáo khoa học: The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2 pot
... this interaction has aneffect on the enzyme activity of the kinase. In thisstudy, we demonstrate that both kinases (SRPK 1a and SRPK1) interact with both scaffold attachment factors(SAFB1 and ... protein-specific kinase involved in mediat-ing the interaction and localization of pre-mRNA splic-ing factors in mammalian cells. J Cell Biol 140, 737–750.9 Nakagawa O, Arnold M, Nakagawa M, Hamada H,Shelton ... thatits additional N-terminal region interacts with scaffold attachment factor B1 (SAFB1) [27].SAFB1 is a protein of the nuclear matrix first dis-covered approximately a decade ago. It was...
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Báo cáo khoa học: Metal exchange in metallothioneins – a novel structurally significant Cd5 species in the alpha domain of human metallothionein 1a ppt
... divided by a factor of 33. UV spectra were acquiredusing a Cary 5G UV-Vis-NIR spectrophotometer (VarianCanada, Mississauga, Canada) in a 1 cm quartz cuvette atroom temperature (22 °C) and recorded ... ESI-TOF mass spectrometer (Waters Micromass,Mississauga, Canada) at room temperature (22 °C), and recorded using the mass lynx software package version4.0. The ESI-TOF spectrometer was calibrated ... funded by the CanadaResearch Chair program, Doug Hairsine (WesternOntario) for advice and discussion on operation of theESI mass spectrometer, and ACD Labs for anacademic trial license for...
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báo cáo khoa học: " The YlmG protein has a conserved function related to the distribution of nucleoids in chloroplasts and cyanobacteria" pdf
... 5'-CACCGAGAAGTCAA-CAGCTCGGTCATCGAC-3' and 5'-TCAAGTCTTC-CAATTTCTACCCAGTGCTGC-3' for AtYLMG1-1, 5'-CCTCAACATATATAACACCATC-3' and 5'-GACAG-GTTCAGGTCATAGAAG-3' ... 5'-GACAG-GTTCAGGTCATAGAAG-3' for At5g21920, 5'-TATCT-GAACACTCCGTTGACGGTA-3' and 5'-CAAAGATAAACGGAATACGATC-3' for At4g27990, 5'-GCAATGG-GAAGCAGTGGTGG-3' and 5'-GGGAGAAGAGACG-GGTTTCG-3' ... inserted 35S-cDNA in the FOX lines,the insertion was amplified by PCR using primers 5'-GTACGTATTTTTACAACAATTACCAACAAC-3' and 5'-GGATTCAATCTTAAGAAACTTTATTGCCAA-3', and then sequenced...
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Tài liệu Báo cáo khoa học: The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression ppt
... inter-actions are mediated through many salt bridges and van der Waals contacts between a 2 and b4 of RRM 1 and b2 and a 1 of RRM 2, respectively (Fig. 6D).Another interesting example of RRM–RRM ... of another protein that acts as a cofactor. Both U2B¢ and CBP20 need a cofactor, U 2A and CBP80, respectively, to recognize RNA. Ternarystructures of these complexes have been solved thatpartially ... protein–proteininteraction are displayed as balls and sticks.This figure was generated using the pro-gramsMOLSCRIPT and RASTER3D [57,58].C. Maris et al. The RRM domain, a plastic RNA-binding platformFEBS...
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Báo cáo khoa học: The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba docx
... fractions was measured and thepurity of pyridoxal kinase was determined by SDS ⁄ PAGE[29] and MALDI-TOF-MS (see Supplementary material).General analytical methodsEnzymatic formation of vitamin ... unphosphorylated dietary precursors catalysed byPKH is required ubiquitously in mammalian tissues[15]. Decreased activity of PKH leads inter alia to a decreased availability of PLP for GAD, which cata-lyses ... Thus,there is an obvious connection between the mainsymptoms of gin-nan sitotoxism and the disregulation of c-aminobutyric acid metabolism. This disregulationhas been explained by reduced GAD activity...
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Báo cáo khoa học: The multi-replication protein A (RPA) system – a new perspective ppt
... exclusively of archaeal RadA protein, a homolog of bacterial RecA, eukaryotic Rad51 and archaeal RadB. This protein is involved in DNA repair and recombination[42,188]PCNA PCNA, or cyclin, is a non-histone ... Dmc1enhances DNA topoisomerase II catenation activity independent of sequence homology. Chromosoma 117,297–302.163 Koshiyama A, Hamada FN, Namekawa SH, IwabataK, Sugawara H, Sakamoto A, Ishizaki ... purification and characterization. Chromosoma102, 631–636.152 Nara T, Hamada F, Namekawa S & Sakaguchi K(2001) Strand exchange reaction in vitro and DNA-dependent ATPase activity of recombinantLIM15...
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Báo cáo khoa học: "The mating system in a Scots pine clonal seed orchard in Poland" pdf
... (Shaw and Allard,198 2a) and natural populations (Neale and Adams, 1985). Apart from the theoreticalvalue of such studies they are also of prac-tical interest, especially ... natural populations(Neale and Adams, 1985; El-Kassaby etal, 1987; Muona and Harju, 1989) and hasbeen explained mainly by the family struc-ture of a stand. In this ... such plantationsare phenotypically or genetically selectedfrom natural or artificial stands, and arereplicated many times as grafts. It is as-sumed that full panmixis occurs...
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