... excessive inflammatoryresponses including enhanced inflammatory cytokineproduction [7] and the release of oxygen free radicals [8]. The relevance of the inflammatory responses to clinicaloutcome ... Hospital, University of Toronto, Ontario, Canada2Assistant Professor, Department of Anaesthesia and Department of Critical Care Medicine, St Michael’s Hospital, University of Toronto, Ontario,CanadaCorrespondence: ... studies have investigated the effects of vasodilators that combine with anti-inflammatory properties inseptic conditions to test the hypothesis that such therapieswould be able to improve microcirculation...