... Kato, Mas-ayuki Shibasaki, Hitoshi Matsushime, Masato Kobori,Jiro Hirosumi and Mr Tsutomu Higashiya at AstellasPharma Inc., and Junko Kawano and Akemi Mats-uoka at Trans Genic Inc. for their helpful ... Fujikawa3,Shun-ichiro Matsumoto2, Takeshi Kurama1, Teruhiko Shimokawa1 and Ichiro Aramori21 Pharmacology Research Labs, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan2 Molecular Medicine ... sig-nificant. Statistical and data analyses were performed using the sas 8.2 software package (SAS Institute Japan Ltd,Tokyo, Japan).AcknowledgementsWe thank Drs Kiyoshi Furuichi, Masao Kato, Mas-ayuki...