báo cáo khoa học: "Treatment of stage I seminoma: is it time to change your practice? " pdf
Tài liệu Báo cáo khoa học: Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1 Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model doc
... of maintenance MDR1 inhibition from birth requiresinvestigation. In addition, more selective inhibitors of MDR1 than CsA are available. CsA is, however, clin-ically used long-term and it might ... approach to the inhibition of substrate synthesis.Future work with neonatal Fabry mice is required to establish a ‘proof of principle’ as to the efficacy of anMDR1 inhibition approach.In summary, ... (stud-ies in progress) and the tissue differences in MDR1expression. Thus, an effect of MDR1 inhibition onGSL biosynthesis in vivo was by no means assured.The possibility of using MDR1 inhibition...
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Tài liệu Báo cáo khoa học: Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain ppt
... catalytic site. Proteinpurification and enzymatic studies have led to the identifi-cation of different isoenzymes distinguished by substratespecificity and resistance to inhibitors. Relevant to thepresent ... protein level,making it difficult to decide which of the ADH genes orproteins is expressed in a certain tissue. In previous studiesemploying Northern blot analysis, tissue distribution of mRNA ... because of their implications in the metabolism of ethanol and retinoic acid. In vitro and in vivo data indicatethat ADH1, ADH3 and ADH4 can oxidize retinol to retinal, with ADH4 having very high...
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Tài liệu Báo cáo khoa học: "TREATMENT OF LONG DISTANCE DEPENDENCIES IN LFG AND TAG: FUNCTIONAL UNCERTAINTY IN LFG IS A COROLLARY IN TAG" ppt
... the identity function. Similarly, we must allow adjoining by any auxiliary tree adjoin- able at 7/(admissibility of adjoining is determined by the success or failure of unification). Thus, if ... tainty accomplishes for LFG can be achieved within the FTAG framework without requiring power beyond that of TAGs. FTAG, as described in this paper, is unlimited in its generative ca- pacity. ... analysis can be given. This extension of RFTAG still does not go beyond TAG and thus is within the class of mildly context-sensitive grammar formalisms de- fined by Joshi [1]. This extension of...
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Báo cáo khoa học: Promoters of type I interferon genes from Atlantic salmon contain two main regulatory regions docx
... NFjB inhibitorPDTC was shown (Fig. 7). PDTC is a metal chelatorwith antioxidant properties which specifically inhibitsNFjB-induced pathways [39]. Secondly, partial inhibi-tion of promoter activity ... transcription start site, which controlssynthesis of a short transcript; (b) a distal region (PR-II) corresponding to position )747 to )413, whichgives rise to a long transcript (Fig. 1). Luciferasereporter ... by binding of IFN-a ⁄ b to the type I IFN receptor resulting in activation of transcription of several hundred IFN-stimulated genes, some of which encode proteins that inhibit viral replication.The...
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Báo cáo khoa học: "Treatment of bipolar disorder: a complex treatment for a multi-faceted disorder" pdf
... problem as it is often retrospectiveand carries the risk of bias and memory distortions; hence it is of questionable reliability and validity.Another problem is that while a specific treatment ... this first stage is practically useless orthat clinicians do not seem to appreciate it. Statistics showthat the vast majority of BD patients receive more thanone medication, with a significant ... outcome of depressioncould be improved by the addition of an antidepressantwithout significantly altering the risk of switch [152].According to earlier studies, switching to mania or hypo-mania...
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Báo cáo khoa học: "Treatment of symptomatic macromastia in a breast unit" pdf
... Because of the barriers between spe-cialities this cross-speciality training is difficult and is not easily accessible with the exception of the UnitedKingdom where an oncoplastic fellowship was ... majority of cases are performed as an isolated procedure; for thatreason our offer is limited to about 20 patients per year.This number might be enough to i mprove oncoplastictraining but it is ... obtained from the patientfor publication o f this case report and accompanyingimages. A copy of the written consent is available forreview by the Editor-in-Chief of this journal.Abbreviations(OBS):...
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Báo cáo khoa học: "Treatment of early uterine sarcomas: disentangling adjuvant modalities" ppt
... agent that binds to theDNA minor groove and has an original mechanism of action involving proteins of the nucleotide excision repairmachinery has shown promising activity in patients withadvanced ... not irradiation, respectively. More ana-lytically, women with stage I- III disease experienced a ben-efit in overall survival (hazard ratio = 0.87, p = 0.03), whilethose with stage IV disease ... observation. Thissignificant randomized trial demonstrated that patientswith LMS did not show the same benefit from radiation aspatients with CSs [34].In patients with LMS, in contrast to patients...
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Báo cáo khoa học: "Treatment of pathologic spinal fractures with combined radiofrequency ablation and balloon kyphoplasty" doc
... metastasis during the investiga-tion after hospitalization. According to the classification of Tomita et al. [12], the patient with 6 points in the scor-ing system, was an eligible candidate ... sensorynerve fibers in the periosteum, which could result in aninhibition of the pain transmission [23]. In addition,PMMA which has a mechanically stabilizing effect playsan important role in pain score ... [9-11].The aim of this article is to present the feasibility of per-forming the combined RFA and balloon kyphoplasty(BKP) in 3 patients with painful spinal metastatic diseasein one session.Materials...
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Báo cáo khoa học: " Brachytherapy of stage II mobile tongue carcinoma. Prediction of local control and QOL" pps
... categorized into fourtypes; 1) papillary or fungating, 2) superficial, 3) ulcera-tive and 4) infiltrating [14]. It was clinically difficult to distinguish the ulcerative type from the infiltrating ... carci-noma of the tongue at the Tokyo Medical and DentalUniversity Hospital. This series included 337 patientswith a minimum follow-up of local disease for 3 years to reflect the nature of ... reproduction in any medium, provided the original work is properly cited.Publish with BioMed Central and every scientist can read your work free of charge"BioMed Central will be the most significant...
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Tài liệu Báo cáo khoa học: Biosynthesis of riboflavin Screening for an improved GTP cyclohydrolase II mutant pdf
... improve-ment of riboflavin fermentation processes.Studies on a riboflavin producer strain of Bacil-lus subtilis showed a significant increase in productivityfollowing the insertion of an additional ... enzymes of the riboflavin biosyntheticpathway have low catalytic rates, the activity of GTPcyclohydrolase II appears to be rate limiting for theoverall productivity of a recombinant B. subtilis ... 3,4-di-hydroxy-2-butanone 4-phosphate synthase are rate-limiting enzymes in riboflavin synthesis of an industrialBacillus subtilis strain used for riboflavin production.J Ind Microbiol Biotechnol...
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