báo cáo khoa học: "P-loop mutations and novel therapeutic approaches for imatinib failures in chronic myeloid leukemia" pps

... ofpoint mutations within the ABL kinase domain of BCR-ABL. Such mutations inhibit the ability of imatinib tobind to BCR-ABL by corrupting the binding sites or pre-venting the kinase domain ... Monitoring CML patientsresponding to treatment with tyrosine kinase inhibitors:review and recommendations for harmonizing currentmethodology for detecting BCR-ABL transcripts and kinasedomain mutations ... domain from assuming the inactiveconformation required for imatinib binding [11]. Point mutations develop in approximately 35% to 70% ofpatients displaying resistance to imatinib, either sponta-neously...

Báo cáo khoa hoc:"Regression markers with uncertain allele transmission for QTL mapping in half-sib designs" ppsx

... marker information on paternal marker alleletransmission were included in the analysis. Inclusion of offspring with incom-plete marker information in QTL mapping results in ... progeny. Progenies withincomplete marker information must be included in the statistical analysis toincrease the statistical power and reduce bias and standard errors of estimates[12].The ... based on genetic markers has gained muchimportance in animal and plant genetics in recent years. The main goal behindidentifying and mapping QTL is to accelerate genetic...

Tài liệu Báo cáo khoa học: Identiﬁcation and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebraﬁsh, Danio rerio docx

... activators. Itcontains at least three distinct structural domains [43]:a fork-head domain at the C-terminus (a sequence of80–100 amino acids forming a motif that is critical for DNA binding and nuclear ... isshared by all FOX proteins, a leucine zipper domain and a C2H2 zinc ﬁnger domain, both of which arethought to help mediate DNA binding and may beinvolved in the induction of dimerization ... regions containing the t-bet and foxp3 genes. Around t-bet, the genes TBK1-bind-ing protein 1, oxysterol-binding protein-like 7 (OS-BPL7) and mitochondrial ribosomal protein L10 werefound in the...

Tài liệu Báo cáo khoa học: Computational processing and error reduction strategies for standardized quantitative data in biological networks doc

... using the protein standard depicted in Fig. 1. Smoothing spline curves through original and normalized data are shown as solid lines.M. Schilling et al. Strategies for standardizing quantitative ... pMOWS, containingHA-EpoR cDNA, was introduced into BaF3 cells by retro-viral transduction. Cell lines stably expressing HA-EpoR(BaF3-HA-EpoR) were selected and maintained in RPMI1640 (Invitrogen, ... Biosciences) for 1 min, and exposed for 10 min on aLumiImager (Roche Diagnostics). All other immunoblotswere incubated with ECL Advance substrate (AmershamBiosciences) for 2 min, and exposed for 1 min...

Tài liệu Báo cáo khoa học: Puriﬁcation and characterization of glutamate N-acetyltransferase involved in citrulline accumulation in wild watermelon doc

... mitochondria [15,30,31], and ornithine isexported to the cytosol to be converted into citrulline and arginine [31,32]. In plants, information on thelocalization of citrulline and arginine biosyntheticenzymes ... N-acetylornithinetransaminase; GAT, glutamate N-acetyltransferase; AOD, N-acetyl-ornithine deacetylase; OCT, ornithine carbamoyltransferase; ASS,argininosuccinate synthase and ASL, argininosuccinate ... that ornith-ine carbamoyltransferase, an enzyme required for thesixth step in the citrulline and arginine pathway, islocalized in chloroplasts in Canavalia lineate [33], rais-ing the possibility...

Tài liệu Báo cáo khoa học: "Exploiting Syntactic and Shallow Semantic Kernels for Question/Answer Classiﬁcation" docx

... In CoNLL-2005.Y. Chen, M. Zhou, and S. Wang. 2006. Reranking answersfrom deﬁnitional QA using language models. In ACL’06.M. Collins and N. Duffy. 2002. New ranking algorithms for parsing and ... SVMs and the above modelssuggest that syntactic information helps tasks suchas question classiﬁcation whereas semantic informa-tion contained in PAS and PASN gives promising re-sults in answer ... Quarteroni and S. Manandhar. 2006. User modelling for Adaptive Question Answering and Information Retrieval. In FLAIRS’06.E. M. Voorhees. 2001. Overview of the TREC 2001 QA track. In TREC’01.D....

Tài liệu Báo cáo khoa học: "Analysing Wikipedia and Gold-Standard Corpora for NER Training" ppt

... 2009.c2009 Association for Computational LinguisticsAnalysing Wikipedia and Gold-Standard Corpora for NER TrainingJoel Nothman and Tara Murphy and James R. CurranSchool of Information TechnologiesUniversity ... explore intra- and inter-corpusconsistency in MUC, CoNLL, and BBN in Section 4.3.1 N-gram tag variationDickinson and Meurers (2003) present a clevermethod for ﬁnding inconsistencies within POS ... Ciaramita and Yasemin Altun. 2005.Named-entity recognition in novel domains with ex-ternal lexical knowledge. In Proceedings of theNIPS Workshop on Advances in Structured Learning for Text and Speech...

Tài liệu Báo cáo khoa học: "Deriving Verbal and Compositional Lexical Aspect for NLP Applications" pptx

... bridge and New York. Weinberg, Amy, Joseph Garman. Jeffery Martin. and Paola Merlo. 1995. Principle-Based Parser for Foreign Language Training in German and Arabic. In Melissa Holland, Jonathan ... selection and the interpretation of events in machine transla- tion and foreign language tutoring applications, re- spectively. 2 Lexical Aspect Following Olsen (To appear in 1997), we distinguish ... fundamental linguistic distinction (cf. (Levin and Rappaport Hovav, To appear) and refer- ences therein). Examples are discussed below. Following Grimshaw (1993) Pinker (1989) and others, we distinguish...

Báo cáo khóa học: O-acetylation and de-O-acetylation of sialic acids in human colorectal carcinoma docx

... asdescribed in Shen et al. [11]. Brieﬂy, OAT activity measuredusing endogenous substrates was performed by incubating 50 lg of protein in 30 lLof50mMpotassium phosphatebuffer, pH 7.0, containing ... avoided puriﬁcation and cloning,remaining elusive despite the efforts of a number of groups.Nevertheless, the information reported here adds consider-ably to our understanding of sialate O-acetylation ... reduction in O-acetylation and not, for example,the increased expression of mucin protein cores [8]. Takentogether these studies indicate that sialate O-acetylationplays a pivotal role in regulating...

Báo cáo khoa học: "Minimized models and grammar-informed initialization for supertagging with highly ambiguous lexicons" pdf

... stage ﬁlls in these missing links.Minimization 2 (MIN2). This stage uses theoriginal minimization formulation for the su-pertagging problem IPoriginal, again using an in- teger programming method ... 3 and 4, summarized below:EM HMM uniformly initialized, EM training.EM+IP IP minimization using initial grammarprovided by EM.EMGIHMM with grammar-informed initializa-tion, EM training.EMGI+IPGIIP ... training.EMGI+IPGIIP minimization using initial gram-mar/lexicon provided by EMGI and addi-tional grammar-informed IP objective. For EM+IP and EMGI+IPGI, the minimization and EM training processes...

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