báo cáo khoa học: "Isolation of specific and biologically active peptides that bind cells from patients with acute myeloid leukemia (AML)" doc
báo cáo khoa học: "Isolation of specific and biologically active peptides that bind cells from patients with acute myeloid leukemia (AML)" doc
... bind cells from leukemia patients Phage clones that bind to leukemia cells were isolated byincubating a library of M13 phage bearing 8 mer pep-tides with BM mononuclear cells from CML-BC patients. After ... screening, and in order to avoid iso-lating patient specific peptides, the screening and profiling were performed with cells from multiple patients with different myeloid leukemia subtypes. It is of interest ... donors). No binding was detected. Thebinding profile of the phage clones was nearly identicalfor AML and CML-BC cells, implying that the binding of the peptides was myeloid leukemia specific rather...
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Báo cáo khoa học: "Inducibility of the endogenous antibiotic peptide β-defensin 2 is impaired in patients with severe sepsis" pptx
... survi-vors and non-survivors of severe sepsis. Despite the limitednumber of patients, the statistical power of the comparison of hBD2 mRNA inducibility between patients with severe sepsis and controls ... imbalanceoccurring in patients with severe sepsis.The importance of plasmatic hBD2 for patients with severesepsis is unclear. In particular, knowledge of the interaction with mediators and effectors of the ... cells and memory T cells. They regulate cytokine production and adhesion-molecule expression, stimulate epithelial cell and fibroblast proliferation, and promote histamine release from mast cells...
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Báo cáo khoa học: Isolation, characterization, sequencing and crystal structure of charybdin, a type 1 ribosome-inactivating protein from Charybdis maritima agg. potx
... highly active and others inactive.If this is the case, the protein that we isolated and studied may be an inactive isoform, and the observedactivity may be due to ‘impurities’ of another highly active ... the mechanism of action of the toxicenzyme [16,17]. It was found that replacement of Tyr(in ricin position 80) with Phe decreased activity by afactor of 15, and replacement with Ser decreased ... bac-teria and fungi. They are distributed throughout theplant kingdom and are active against ribosomes from different species, although the level of activity dependson the source of the RIP and of...
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Báo cáo khoa học: "Isolation of Aspergillus spp. from the respiratory tract in critically ill patients: risk factors, clinical presentation and outcome" potx
... (COPD), immunosuppression and trans-plantation in the patients with Aspergillus infection, and agreater prevalence of solid neoplasms in the patients with Candida infection. With regard to risk factors ... beforeisolation of Aspergillus spp. was 32.1 ± 21.4 days. Previoususe of fluconazole was recorded in eight of the 36 patients (22.2%) with isolation of Aspergillus spp., and in 41 of the105 patients ... infected with fungi, and 720 were classified as noncolonized, uninfected patients. Colonization with Candida spp. was diagnosed in 880(49.8%) patients, Candida spp. infection in 105 (5.9%), and infection...
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Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx
... [10,11]suggested that the most prevalent form of MetS isassociated with abdominal (visceral) obesity and that this type of obesity contributes to insulin resistance(IR) and the increased release of cytokines, ... sug-gested that obesity itself may be the underlying causefor a hypoandrogenic state.Kaplan et al. [55] examined testosterone levels in864 subjects with and without MetS and found that obese men with ... adiposity,smoking and alcohol consumption contributed to EDin men with T2DM. The authors suggested that ED isassociated with low BAT and FT, but not TT, and that ED is more frequently observed in men with higher...
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Tài liệu Báo cáo khoa học: Analysis of proteins and peptides on a chromatographic timescale by electron-transfer dissociation MS ppt
... 6271dimethylation of Arg, monomethylation, dimethylation and trimethylation of Lys, acetylation and ubiquitina-tion of Lys, and phosphorylation of Ser and Thr [16–18]. Combinations of these modifications ... Fragmentation scheme for production of ions of type c¢ and z¢Æby reaction of a low-energy electron with a multiply protonatedpeptide.ETD-MS analysis of peptides and proteins N. D. Udeshi et al.6270 ... analysis of tryptic peptides from paxillin. Forty-five different sites of phosphorylation were also identified on this protein.The detection and location of Ser and Thr residuesmodified with the...
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Tài liệu Báo cáo khoa học: Binding of N- and C-terminal anti-prion protein antibodies generates distinct phenotypes of cellular prion proteins (PrPC) obtained from human, sheep, cattle and mouse doc
... intensities of the di- (d), mono- (j) and nonglycosylated isoform (m) of PrPCwere quantified and calcu-lated as percentages of the total signal. The glycoforms of the pro-tein bands were analyzed ... indicated.(B) The glycoforms of the protein bands were analyzed by calcula-tion of the percentages of the di- (d), mono- (j) and nonglycosy-lated (m) isoform as arithmetic means of separate gel runs. ... di-glycosylated band, and mAbs6H4, SAF60, SAF70 and SAF84 showed the higheststaining with the overlapping bands of nonglycosylatedfull-length PrPC and glycosylated truncated isoforms(Fig. 5A–C)....
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... fosfomycinbinding, and in view of the multitude of interactions, it wasassumed that deletion of a single interaction would not leadto a complete loss of fosfomycin binding. Therefore it wasargued that ... ligand binding. The loop region of the upper domainmoves towards the active site of the enzyme, thus shieldingthe substrates (and ligands) from bulk solvent. A detailedthermodynamic study of ... MurA and the K22V mutant proteinincubated with 10 mMUDPNAG and 1 mMfosfomycin prior to digestion. The mass peak of 1616 (m/z) is due to the peptide of amino acids 104–120 and on binding of...
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Tài liệu Báo cáo khoa học: "Order of Subject and Predicate in Scientific Russia" pptx
... variety of classes of words. Almost 1/4 of the clauses contain no subject. The results of the above study indicate that the word order in scientific Russian is sufficiently different from that of ... 7.96% of the total. The word order was Subject - Predicate in all instances without exception. 3. The predicate slot was filled by an adjective in 496 instances, or 17. 02% of the total. Of ... filled by past participle was 204, or 7.00% of the total. 5. The clauses contained no subject in 657 in- stances, or 22.55% of the total. Of that num- ber, the predicate slot was filled...
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Tài liệu Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking pdf
... extracellular and a b-transmembrane and intracellularsubunits, held together by disulfide bonds. Moreover, part of the a-subunit of the receptor is shed from thyroid and transfected L cells. To understand ... removal of the unbound Ig, cells were washed three times with cold incubation medium, once with prewarmed incubationmedium and incubated at 37 °C for various periods of times. Cells were incubated with ... °Cwiththesamemedium containing IBMX (0.5 mM) and 0–100 IUÆL)1 of bTSH. The incubation was stopped by aspiration of themedium and addition of 400 lLÆwell)1 of 1Mperchloricacid. The cells...
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