... reg-ulatory enzyme in the pathway. Malonyl-CoA serves as the basic chain-elongating substrate for the formation of long-chain saturated fatty acids catalyzed by FAS.It should be noted that cytoplasmic ... acetyl-CoA car-boxylase; AMPK, 5¢ AMP kinase; CPT, carnitine palmitoyltransfer-ase; FAS, fatty acid synthase; MCD, malonyl-CoA decarboxylase;OAA, oxaloacetate; TCA, tricarboxylic acid.M. J. Wolfgang ... – the sole precursor of fatty acids. The initial and committed step of de novofatty acid synthesis is the carboxylation of acetyl-CoAto form malonyl-CoA, catalyzed by ACC – the key reg-ulatory...