... operative and non-operative treatments for AVN, pain management in patients with AVN remainschallenging. Prostaglandins play an important role in inflammatory responses and cell differentiation. ... Nakae K, Saito K, Iino T, Yamamoto N, Wakabayashi M, YoshikawaS, Matsushima S, Miyashita H, Sugimoto H, Kiba A, Gupta J: A prostacyclin receptor antagonist inhibits the sensitizedrelease of ... potential and analge-tic efficiency of the vasoactive prostacyclin analogue iloprost. The stable prostacyclin analogue iloprost is approved for treat-ment of critical ischaemia occurring secondarily...