Mollison’s Blood Transfusion in Clinical Medicine - part 3 pdf
Chapter 003. Decision-Making in Clinical Medicine (Part 2) pdf
... Chapter 0 03. Decision-Making in Clinical Medicine (Part 2) The following three examples introduce the subject of clinical reasoning: A 46-year-old man presents to his internist with ... would be inaccurate if the clinical (pretest) picture of the patient being tested indicates a low probability of disease (e.g., a 30 -year-old woman with no risk factors). As illustrated in this ... the sort encountered daily in clinical medicine, with great efficiency. Clinicians rely on three basic types of heuristics. When assessing a particular patient, clinicians often weigh the probability...
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Chapter 003. Decision-Making in Clinical Medicine (Part 3) ppt
... disease is the underlying cause. The absence of a resting Chapter 0 03. Decision-Making in Clinical Medicine (Part 3) Diagnostic Hypothesis Generation Cognitive scientists studying the thought ... make teaching diagnostic reasoning difficult is that expert clinicians do not follow a fixed pattern in patient examinations. From the outset, they are generating, refining, and discarding diagnostic ... examiner to the exclusion of all other inputs until answered, allowing the examiner to move on to the next specific question. Negative findings are often as important as positive ones in establishing...
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Chapter 064. The Practice of Genetics in Clinical Medicine (Part 3) potx
... representing another confounding variable in the pedigree analysis. Some of the aforementioned features of the family history are illustrated in Fig. 6 4-1 . In this example, the proband, a 36 -year-old ... family history of cancer. Chapter 064. The Practice of Genetics in Clinical Medicine (Part 3) Recall of family history is often inaccurate. This is especially so when the history is remote ... analysis in this family is to test the cancer-affected 42-year-old living cousin for the presence of a BRCA1 or BRCA2 mutation. If a mutation is found, then it is possible to test for this particular...
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Chapter 064. The Practice of Genetics in Clinical Medicine (Part 7) pdf
... Prevention of urinary tract infections Kidney transplantation Nephrogenic XL, AR AVPR2, Fluid Chapter 064. The Practice of Genetics in Clinical Medicine (Part 7) Therapeutic Interventions ... Parkinson disease AD SNCA, PARK2 Amantadine, anticholinergics, levodopa, monoamine oxidase B inhibitors Wilson disease AR ATP7B Zinc, trientene Abbreviations: AD, autosomal dominant; ... available for an increasing number of genetic disorders, whether identified through population-based screening or directed testing (Table 6 4-2 ). Although the strategies for therapeutic interventions...
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Chapter 065. Gene Therapy in Clinical Medicine (Part 2) pdf
... transcription factor complex involved in Chapter 065. Gene Therapy in Clinical Medicine (Part 2) Figure 6 5-1 Indications in gene therapy clinical trials. The chart divides clinical gene transfer ... reconstitution of the immune system, including documented responses to standard childhood vaccinations, clearing of infections, and remarkable gains in growth occurred in most of the treated children. ... splenomegaly, rising white counts, and the emergence of a single clone of T cells. In these children, the retroviral vector had integrated within a gene, LMO-2 (LIM only-2), which encodes...
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Chapter 065. Gene Therapy in Clinical Medicine (Part 3) docx
... factor (VEGF) inhibitors such as angiostatin, or through the use of RNAi-mediated Chapter 065. Gene Therapy in Clinical Medicine (Part 3) Long-Term Expression in Genetic Disease: In Vivo Gene ... hepatocytes, long-term expression can be achieved even in the absence of integration. Clinical trials using recombinant AAV vectors are now ongoing for muscular dystrophies, α1-antitrypsin deficiency, ... affected) into the range of 5% greatly improves the phenotype of the disease. Preclinical studies with recombinant AAV vectors infused into skeletal muscle or liver have resulted in long-term...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 3) pot
... dysfunction after spinal cord injury reflects demyelination, and both ES cells and marrow-derived stem cells are able to facilitate remyelination after experimental spinal cord injury. Clinical trials ... for stem cell therapies include spinal cord injury, amyotrophic lateral sclerosis, stroke, traumatic brain injury, Batten disease, and Parkinson's disease. In Parkinson's disease, ... Applications of Stem Cell Biology in Clinical Medicine (Part 3) Diabetes Mellitus The success of islet cell and pancreas transplantation provides proof of concept for a cell-based approach for type...
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Neurology Seminars in Clinical Neurology - part 3 pdf
... Botulinum toxin in the management of ble-pharospasm. Arch Neurol 1986; 43: 380 38 2.Jankovic J, Ford J. Blepharospasm and orofacial-cervical dystonia: clinical and pharmacological findings in 100 ... heavy chain and a light chain. The for-mer is important in binding to the presynaptic neuro-muscular terminals, whereas the latter is released intothe terminals. The light chain is a zinc metalloen-dopeptidase, ... Tetrabenazine,being predominantly a presynaptic dopamine-deplet-ing agent, may be tried in some patients.Other drugs such as anticonvulsants (carba-mazepine) have been effective in individual...
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Neuroimmunology in Clinical Practice - part 3 pdf
... high-affinity interleukin-2 receptor, anti-CD25); alemtuzumab (anti-CD52,Campath 1H); rituximab (anti-CD20); anti-CD40L/-CD154 (IDEC- 131 ); anti-IL-12,anti-CD6; anti-CD3 (OKT3); anti-Vβ5.2/5 .3 +T ... cells; anti-CD4; integrin inhibitorsLymphocyte-specific cytoplasmic protein – tyrosine kinase P56lck; zeta-associatedprotein (ZAP )-7 0; protein kinase C theta; mitogen-activated protein kinase; nuclearfactor ... evolving inter-ventions are shown in Table 3. 6. There is an extens-ive number of clinical trials currently ongoing in MS.These are listed at http://www.nationalmssociety.org/ pdf/ research/clinicaltrials .pdf. ReferencesAboul-Enein,...
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Blood Transfusion in Clinical Practice Edited by Puneet Kaur Kochhar ppt
... allogeneic blood transfusion: a meta-analysis of published randomized and nonrandomized studies. Transfusion Medicine. 1996;6 :32 5-8 . Erslev, AJ. Erythropoietin. N Engl J Med. 1991 ;32 4: 133 9-1 34 4 Erstad, ... C3a, in operatively salvaged blood. Aust NZ Jour Surg. 1991;61 :30 2 -3 95. Blood Transfusion in Clinical Practice 84Anaemia in pregnancy: It is hard to determine the prevalence of anaemia in ... used include thrombin, collagen and fibrin glue. A gelatin matrix containing thrombin was shown to stop bleeding in cardiac surgery patients within 10 minutes in 94% of patients(Oz 2000). Fibrin...
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