báo cáo khoa học: "Implementing health research through academic and clinical partnerships: a realistic evaluation of the Collaborations for Leadership in Applied Health Research and Care (CLAHRC)" pot

... L Open AccessImplementing health research through academic and clinical partnerships: a realistic evaluation of the Collaborations for Leadership in Applied Health Research and Care (CLAHRC)Jo ... academic and clinical partnerships: a realistic evaluation of the Collaborations for Leadership in Applied Health Research and Care (CLAHRC). Implementation Science 2011 6:74.Rycroft-Malone et al. ... institutions and local health services called Collaborations for Leadership in Applied Health Research and Care (CLAHRC). They have been funded to increase capacity and capability to produce and implement...

báo cáo khoa học: " Implementing telehealth to support medical practice in rural/remote regions: what are the conditions for success?" ppsx

... exploreperceptions of physicians and managers regarding the impact of telehealth on clinical practice and the organisation of health care services, as well as the conditions for improving telehealth implementation. ... delivery of health care services, is considered as a means to answer many of the imperativescurrently challenging health care systems. In Canada, many telehealth projects are taking place, mostlytargeting ... questions dealingwith the effects of telehealth on clinical practice and organisation of care. Finally, questions addressed theiropinion about telehealth benefits and limitations, as wellas their...

báo cáo khoa học: " What can management theories offer evidence-based practice? A comparative analysis of measurement tools for organisational context" potx

... evidence-based practice (EBP) in healthcare.Methods: A structured search of the major healthcare and management databases for measurement tools from four domains: research utilisation (RU), research activity ... repre-sented in any tool: 'involving the individual','policies and infrastructures','managerial attributes','accessing informa-tion', and 'supporting teamwork'. ... tools in healthcare, and to improve the delineation of the social and humanaspects of EBP in healthcare. If this preliminary stageproves fruitful in highlighting the utility of widening the pool...

Báo cáo y học: "Systematic review: Intra-aortic balloon counterpulsation pump therapy: a critical appraisal of the evidence for patients with acute myocardial infarction" doc

... functionthan those in the Randomized IABP Trial.Critical appraisal of randomized clinical trials of IABP therapy in AMI patientsThorough critical appraisal involves determining the validity of the study ... stand-ard care. Intracoronary thrombolysis was used in 42% of patients later randomized to IABP therapy compared to46% of patients in the standard therapy arm. Intravenousheparin was used for ... not broadsince data for this economic analysis was only based oninhospital billings. It may be argued that from an economicstandpoint, the advantages or disadvantages of IABP ther-apy may be...

báo cáo khoa học: "European health research and globalisation: is the public-private balance right?" potx

... - and to‘tran slate’ research into marketable and profit-makingproducts. Nevertheless, as well as molecular and clinical research, the seventh Research Framework Programmehas also a ‘pillar’ ... health care market. Yet healthcaresystems are publicly regulated and paternalistic, and ‘trade’ is at cost to the public as payers of health insur-ance and taxes. Equally, the emphasis on laboratoryresear ... innovation, and theirimplementation in health and healthcare systems, shouldbe calculated and set again st the costs of alternatives. The pharmaceutical industry is closely linked to the major global...

Báo cáo khoa học: 15-Deoxy D12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor c in human erythroleukemia cells ppt

... oxidase A AGGACA a AGGTCA [54]Acyl-CoA oxidase B AGGTAG a AGGTCA [54]Lipoprotein Lipase TGCCCT t TCCCCC [58]Apolipoprotein AII CAACCT t TACCCT [68]Enoyl-CoA hydratase GACCTA tt GAACTA t TACCTA ... to the proposal that clinically PPARc ligands mayattenuate the synthesis and action of TXA2 and, in turn, may exert a beneﬁcial effect on cardiovascularcomplications in patients with diabetes ... platelet activation and aggregation and a constrictor of vascular and bron-chial smooth muscle and together with prostacyclin, for example, it plays a key role in the maintenance of haemostasis...

Tài liệu Báo cáo khoa học: High-afﬁnity ligand binding by wild-type/mutant heteromeric complexes of the mannose pptx

... a ﬂattened b-barrel [16]. Ligand bindingexperiments have mapped the Man-6-P bindingdomains mainly to repeats 3 and 9, wherein mutation of critical residues can reduce ligand afﬁnity [17], and such ... format from the amino terminus to the carboxyl terminus, with repeats of the ectodomain shown asrectangles. The shaded rectangles indicate repeats 3 and 9, towhich the main determinants of Man-6-P ... binding ligand independently. The tables indicate the amounts of the various cDNAs transfected into cells for each condition and apply to the data shown both above and below the table. Valuesrepresent...

Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer potx

... Transwell insert (24-well insert; poresize, 8 lm; Corning, Inc., Corning, NY, USA) assay toevaluate PC9 cell migration and invasion in vitro. In both the migration assay and the invasion assay, ... go awry in human cancers.Experimental proceduresCells and cultures The human lung cancer cell line A5 49 was obtained from the American Type Culture Collection (Manassas, VA,USA) and maintained ... Dif-ferent miRNAs have been implicated in the formation of neoplasms, malignant progression, and metastasis.To examine the potential miRNA targets of EGFR sig-naling, we used the miRHuman_10.0_070802...

Báo cáo khoa học: Chick embryo anchored alkaline phosphatase and mineralization process in vitro Influence of Ca 2+ and nature of substrates doc

... biochemical markers of osteoblastactivity [1–4]. The role of bALP in mineral formation wasevidenced in the case of hypophosphatasia, an inheritabledisorder leading to a defective bone formation and ... Hypophosphatasia and the role of alkalinephosphatase in skeletal mineralization. Endocr. Rev. 15, 439–461.6. Narisawa, S., Fro¨hlander, N. & Millan, J.L. (1997) Inactivation of two mouse alkaline ... mineral formation. There was noformation of any HA after 144 h incubation time in the presence of either ADP or ATP in hydrolysing mediumcontaining GPI-bALP and excess of calcium (to compen-sate...

Báo cáo khoa học: Multifunctional host defense peptides: functional and mechanistic insights from NMR structures of potent antimicrobial peptides docx

... Buck-Koehntop B, Thennarasu S, Rama-moorthy A & Veglia G (2006) Structures of the dimeric and monomeric variants of magainin antimicrobialpeptides (MSI-78 and MSI-594) in micelles and bilayersby ... used antibioticssuch as penicillin, streptomycin, vancomycin and ﬂuoro-quinolones has been increasing at an alarming rate in recent years [1,2]. The Infectious Diseases Society of America reported ... selectivity, and anti-endotoxic activity. Biochemistry 46, 5864–5874.53 Bhunia A, Domadia PN & Bhattacharjya S (2007)Structural and thermodynamic analyses of the interac-tion between melittin and...

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